N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-6-(4-fluorophenyl)-5-methylpyridine-2-carboxamide 1-oxide

Base Information

Chemical Name:N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-6-(4-fluorophenyl)-5-methylpyridine-2-carboxamide 1-oxide
CAS No.:1195780-82-5
Molecular Formula:C₃₀H₂₃F₂N₅O₄
Molecular Weight:555.541
Hs Code.:

Synonyms:N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-6-(4-fluorophenyl)-5-methylpyridine-2-carboxamide 1-oxide

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Chemical Property of N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-6-(4-fluorophenyl)-5-methylpyridine-2-carboxamide 1-oxide

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Technology Process of N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-6-(4-fluorophenyl)-5-methylpyridine-2-carboxamide 1-oxide

There total 9 articles about N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-6-(4-fluorophenyl)-5-methylpyridine-2-carboxamide 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1175127-69-1
6-(4-fluorophenyl)-5-methylpyridine-2-carboxylic acid 1-oxide

: 1195781-35-1
N-[6-(4-amino-3-fluorophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

: 1195780-82-5
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-6-(4-fluorophenyl)-5-methylpyridine-2-carboxamide 1-oxide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In ISOPROPYLAMIDE; at 20 ℃; for 6h;

Reference yield:

: 1195781-27-1
benzyl {4-[(6-aminopyridin-3-yl)oxy]-2-fluorophenyl}carbamate

: 1195780-82-5
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-6-(4-fluorophenyl)-5-methylpyridine-2-carboxamide 1-oxide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 3 h / 80 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

3.1: trifluoroacetic anhydride / tetrahydrofuran / 3 h / 20 °C

3.3: 4 h / 20 °C

4.1: ISOPROPYLAMIDE / 0 - 20 °C

5.1: water; barium(II) hydroxide / 1,2-dimethoxyethane / 16 h / 90 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / ISOPROPYLAMIDE / 6 h / 20 °C

With pyridine; water; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic anhydride; barium(II) hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide;

Reference yield:

: 399-95-1
4-amino-3-fluorophenol

: 1195780-82-5
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-6-(4-fluorophenyl)-5-methylpyridine-2-carboxamide 1-oxide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C

2.1: caesium carbonate / dimethyl sulfoxide / 6 h / 20 °C

3.1: water; iron; calcium chloride / ethanol / 8 h / Reflux

4.1: pyridine / 3 h / 80 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

6.1: trifluoroacetic anhydride / tetrahydrofuran / 3 h / 20 °C

6.3: 4 h / 20 °C

7.1: ISOPROPYLAMIDE / 0 - 20 °C

8.1: water; barium(II) hydroxide / 1,2-dimethoxyethane / 16 h / 90 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / ISOPROPYLAMIDE / 6 h / 20 °C

With pyridine; water; iron; sodium hydrogencarbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic anhydride; calcium chloride; barium(II) hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; ISOPROPYLAMIDE; water; dimethyl sulfoxide; N,N-dimethyl-formamide;