3-acetylamino-1-(4-iodo-phenyl)-1H-pyrazole-4-carboxylicacid ethyl ester

Base Information

Chemical Name:3-acetylamino-1-(4-iodo-phenyl)-1H-pyrazole-4-carboxylicacid ethyl ester
CAS No.:1335105-20-8
Molecular Formula:C₁₄H₁₄IN₃O₃
Molecular Weight:399.188
Hs Code.:

Synonyms:3-acetylamino-1-(4-iodo-phenyl)-1H-pyrazole-4-carboxylicacid ethyl ester

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Chemical Property of 3-acetylamino-1-(4-iodo-phenyl)-1H-pyrazole-4-carboxylicacid ethyl ester

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Technology Process of 3-acetylamino-1-(4-iodo-phenyl)-1H-pyrazole-4-carboxylicacid ethyl ester

There total 3 articles about 3-acetylamino-1-(4-iodo-phenyl)-1H-pyrazole-4-carboxylicacid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 15250-36-9
3-acetylamino-1H-pyrazole-4-carboxylic acid ethyl ester

: 589-87-7
1,4-bromoiodobenzene

: 1335105-20-8
3-acetylamino-1-(4-iodo-phenyl)-1H-pyrazole-4-carboxylicacid ethyl ester

Guidance literature:: With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; copper(l) iodide; In 1,4-dioxane; at 110 ℃; for 48h; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.05.056

Reference yield:

: 6994-25-8,103259-35-4,19750-02-8
3-amino-4-pyrazolecarboxylic acid ethyl ester

: 1335105-20-8
3-acetylamino-1-(4-iodo-phenyl)-1H-pyrazole-4-carboxylicacid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 4 h / 100 °C

2: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium phosphate / 1,4-dioxane / 48 h / 110 °C / Inert atmosphere

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; copper(l) iodide; In 1,4-dioxane; 2: Ullmann-Finkelstein reaction;
DOI:10.1016/j.ejmech.2011.05.056

Reference yield:

: 94-05-3,42466-69-3
ethyl (ethoxymethylene)cyanoacetate

: 1335105-20-8
3-acetylamino-1-(4-iodo-phenyl)-1H-pyrazole-4-carboxylicacid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 6 h / 20 °C

2: 4 h / 100 °C

3: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium phosphate / 1,4-dioxane / 48 h / 110 °C / Inert atmosphere

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; copper(l) iodide; hydrazine hydrate; In 1,4-dioxane; ethanol; 3: Ullmann-Finkelstein reaction;
DOI:10.1016/j.ejmech.2011.05.056