(+)-(3R,5S)-methyl 2-benzyl-5-formyl-3,5-dimethylisoxazolidine-3-carboxylate

Base Information

Chemical Name:(+)-(3R,5S)-methyl 2-benzyl-5-formyl-3,5-dimethylisoxazolidine-3-carboxylate
CAS No.:1593585-81-9
Molecular Formula:C₁₅H₁₉NO₄
Molecular Weight:277.32
Hs Code.:

Synonyms:(+)-(3R,5S)-methyl 2-benzyl-5-formyl-3,5-dimethylisoxazolidine-3-carboxylate

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Chemical Property of (+)-(3R,5S)-methyl 2-benzyl-5-formyl-3,5-dimethylisoxazolidine-3-carboxylate

Chemical Property:

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Technology Process of (+)-(3R,5S)-methyl 2-benzyl-5-formyl-3,5-dimethylisoxazolidine-3-carboxylate

There total 3 articles about (+)-(3R,5S)-methyl 2-benzyl-5-formyl-3,5-dimethylisoxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78-85-3,25120-30-3
2-methylpropenal

: 1206188-40-0
C₁₁H₁₃NO₃

: 1593585-81-9
(+)-(3R,5S)-methyl 2-benzyl-5-formyl-3,5-dimethylisoxazolidine-3-carboxylate

Guidance literature:: With [Ru(η5-cyclopentadienyl)(BIPHOP-F)(acetone)][SbF6]; In toluene; at -20 ℃; for 144h; enantioselective reaction;
DOI:10.1021/jo5001737

Reference yield:

: 78-85-3,25120-30-3
2-methylpropenal

: 1206188-40-0
C₁₁H₁₃NO₃

: (+)-(3S,5R)-methyl 2-benzyl-5-formyl-3,5-dimethylisoxazolidine-3-carboxylate

: 1593585-81-9
(+)-(3R,5S)-methyl 2-benzyl-5-formyl-3,5-dimethylisoxazolidine-3-carboxylate

Guidance literature:: 2-methylpropenal; With [Ru(η5-cyclopentadienyl)(BIPHOP-F)(acetone)][SbF6]; In tert-butyl methyl ether; at -10 ℃; for 0.0833333h; Inert atmosphere;

C₁₁H₁₃NO₃; In tert-butyl methyl ether; at -10 ℃; for 144h; Time; Solvent; Concentration; Overall yield = 90 %; Overall yield = 62.6 mg; enantioselective reaction; Inert atmosphere;
DOI:10.1021/jo5001737

Reference yield:

: 78-85-3,25120-30-3
2-methylpropenal

: 1206188-40-0
C₁₁H₁₃NO₃

: (+)-(3S,5R)-methyl 2-benzyl-5-formyl-3,5-dimethylisoxazolidine-3-carboxylate

: (+)-(3R,5R)-methyl 2-benzyl-5-formyl-3,5-dimethylisoxazolidine-3-carboxylate

: 1593585-81-9
(+)-(3R,5S)-methyl 2-benzyl-5-formyl-3,5-dimethylisoxazolidine-3-carboxylate

: 1593586-00-5
(+)-(3S,5S)-methyl 2-benzyl-5-formyl-3,5-dimethylisoxazolidine-3-carboxylate

Guidance literature:: With [Ru(η5-cyclopentadienyl)(BIPHOP-F)(acetone)][SbF6]; In toluene; at 0 ℃; for 120h; Temperature; Time; Concentration; Overall yield = 74 %; enantioselective reaction;
DOI:10.1021/jo5001737