Technology Process of HEXADECANOIC-7,7,8,8-D4 ACID
There total 13 articles about HEXADECANOIC-7,7,8,8-D4 ACID which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 85 percent / NBS; PPh3 / dimethylformamide / 1 h / 0 °C
2: 73 percent / BuLi / tetrahydrofuran; hexane / -78 - 20 °C
3: NBS / acetone; H2O / 0.02 h / -30 °C
4: 97 percent / LiAlH4 / diethyl ether / 20 °C
5: 92 percent / Et3N / CH2Cl2 / 2 h / 20 °C
6: 95 percent / LiAlH4 / diethyl ether / 16 h / 20 °C
7: 97 percent / D2 / RhCl(PPh3)3 / benzene / 36 h
8: 89 percent / aq. HCl / methanol / 24 h / 20 °C
9: IBX / dimethylsulfoxide / 12 h / 20 °C
10: 88 mg / H2SO4; CrO3 / acetone; H2O
With
chromium(VI) oxide; hydrogenchloride; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; sulfuric acid; triethylamine; triphenylphosphine; deuterium; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
RhCl(PPh3)3;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; benzene;
10: Jones oxidation;
DOI:10.1021/jo061592s
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 73 percent / BuLi / tetrahydrofuran; hexane / -78 - 20 °C
2: NBS / acetone; H2O / 0.02 h / -30 °C
3: 97 percent / LiAlH4 / diethyl ether / 20 °C
4: 92 percent / Et3N / CH2Cl2 / 2 h / 20 °C
5: 95 percent / LiAlH4 / diethyl ether / 16 h / 20 °C
6: 97 percent / D2 / RhCl(PPh3)3 / benzene / 36 h
7: 89 percent / aq. HCl / methanol / 24 h / 20 °C
8: IBX / dimethylsulfoxide / 12 h / 20 °C
9: 88 mg / H2SO4; CrO3 / acetone; H2O
With
chromium(VI) oxide; hydrogenchloride; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; sulfuric acid; triethylamine; deuterium; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
RhCl(PPh3)3;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; dimethyl sulfoxide; acetone; benzene;
9: Jones oxidation;
DOI:10.1021/jo061592s
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 97 percent / D2 / RhCl(PPh3)3 / benzene / 36 h
2: 89 percent / aq. HCl / methanol / 24 h / 20 °C
3: IBX / dimethylsulfoxide / 12 h / 20 °C
4: 88 mg / H2SO4; CrO3 / acetone; H2O
With
chromium(VI) oxide; hydrogenchloride; sulfuric acid; deuterium; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
RhCl(PPh3)3;
In
methanol; water; dimethyl sulfoxide; acetone; benzene;
4: Jones oxidation;
DOI:10.1021/jo061592s
