Technology Process of 4'-(α-D-mannopyranosyloxy)-biphenyl-4-carboxylic acid
There total 4 articles about 4'-(α-D-mannopyranosyloxy)-biphenyl-4-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 4'-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyloxy)-biphenyl-4-carboxylate;
With
sodium methylate;
In
methanol;
at 20 ℃;
for 95h;
With
lithium hydroxide;
In
methanol;
In
methanol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: boron trifluoride diethyl etherate / toluene / 30 h / 30 °C
2.1: caesium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 14 h / 80 °C / Inert atmosphere
3.1: sodium methylate / methanol / 95 h / 20 °C
3.3: Dowex 50 x 8
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; boron trifluoride diethyl etherate; sodium methylate; caesium carbonate;
tris-(dibenzylideneacetone)dipalladium(0);
In
1,4-dioxane; methanol; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: boron trifluoride diethyl etherate / toluene / 30 h / 30 °C
2.1: caesium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 14 h / 80 °C / Inert atmosphere
3.1: sodium methylate / methanol / 95 h / 20 °C
3.3: Dowex 50 x 8
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; boron trifluoride diethyl etherate; sodium methylate; caesium carbonate;
tris-(dibenzylideneacetone)dipalladium(0);
In
1,4-dioxane; methanol; toluene;
