N-[3,5-bis(trifluoromethyl)benzyl]-4-phenyl-N,2,6-trimethylnicotinamide

Base Information

• Chemical Name: N-[3,5-bis(trifluoromethyl)benzyl]-4-phenyl-N,2,6-trimethylnicotinamide
• CAS No.: 1303445-86-4
• Molecular Formula: C₂₄H₂₀F₆N₂O
• Molecular Weight: 466.426
• Mol file: 1303445-86-4.mol

Synonyms:N-[3,5-bis(trifluoromethyl)benzyl]-4-phenyl-N,2,6-trimethylnicotinamide

Chemical Property of N-[3,5-bis(trifluoromethyl)benzyl]-4-phenyl-N,2,6-trimethylnicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[3,5-bis(trifluoromethyl)benzyl]-4-phenyl-N,2,6-trimethylnicotinamide

There total 4 articles about N-[3,5-bis(trifluoromethyl)benzyl]-4-phenyl-N,2,6-trimethylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

C14H12ClNO + N-[3,5-bis(trifluoromethyl)benzyl]methylamine hydrochloride → N-[3,5-bis(trifluoromethyl)benzyl]-4-phenyl-N,2,6-trimethylnicotinamide (1303445-86-4)

Guidance literature:

With triethylamine; In dichloromethane; for 1h; Reflux;

DOI:10.1016/j.bmc.2011.02.031

Reference yield:

ethyl 2,6-dimethyl-4-phenylpyridine-3-carboxylate (4350-44-1) → N-[3,5-bis(trifluoromethyl)benzyl]-4-phenyl-N,2,6-trimethylnicotinamide (1303445-86-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol / 18 h / Reflux

2: thionyl chloride / 4 h / Reflux

3: triethylamine / dichloromethane / 1 h / Reflux

With thionyl chloride; triethylamine; sodium hydroxide; In ethanol; dichloromethane;

DOI:10.1016/j.bmc.2011.02.031

Reference yield:

2,6-dimethyl-4-phenylnicotinic acid (401835-18-5) → N-[3,5-bis(trifluoromethyl)benzyl]-4-phenyl-N,2,6-trimethylnicotinamide (1303445-86-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 4 h / Reflux

2: triethylamine / dichloromethane / 1 h / Reflux

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1016/j.bmc.2011.02.031

upstream raw materials:

2,6-dimethyl-4-phenylnicotinic acid

ethyl 2,6-dimethyl-4-phenylpyridine-3-carboxylate

(E)-benzalacetone

Refernces