6-amino-8-(4-chlorophenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile

Base Information

• Chemical Name: 6-amino-8-(4-chlorophenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile
• CAS No.: 83049-51-8
• Molecular Formula: C₁₉H₁₆ClN₅
• Molecular Weight: 349.823

Synonyms:6-amino-8-(4-chlorophenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile

Chemical Property of 6-amino-8-(4-chlorophenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-amino-8-(4-chlorophenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile

There total 2 articles about 6-amino-8-(4-chlorophenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-Methyl-4-piperidone (1445-73-4) + 4-chlorobenzaldehyde (104-88-1) + malononitrile (109-77-3) → 6-amino-8-(4-chlorophenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile (83049-51-8)

Guidance literature:

1-Methyl-4-piperidone; malononitrile; With pyrrolidine; In ethanol; for 0.00833333h; Sonication;

4-chlorobenzaldehyde; In ethanol; for 0.0166667h; Sonication;

DOI:10.1016/j.tet.2016.02.023

Reference yield:

1-Methyl-4-piperidone (1445-73-4) + butanedinitrile (110-61-2) + 4-chlorobenzaldehyde (104-88-1) → 6-amino-8-(4-chlorophenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile (83049-51-8)

Guidance literature:

In methanol;

Reference yield: 89.0%

6-amino-8-(4-chlorophenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile (83049-51-8) → 6-amino-8-(4-chlorophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline-5,7-dicarbonitrile (83049-60-9)

Guidance literature:

With sodium hydroxide; In water; for 0.0333333h; Sonication;

DOI:10.1016/j.tet.2016.02.023

upstream raw materials:

1-Methyl-4-piperidone

butanedinitrile

4-chlorobenzaldehyde

malononitrile

Downstream raw materials:

1-(4-chlorophenyl)-4-cyano-3-methoxy-7-methyl-5,6,7,8-tetrahydro-2,7-naphthyridine

6-amino-8-(4-chlorophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline-5,7-dicarbonitrile

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 83049-51-8 6-amino-8-(4-chlorophenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile

Send

Send

Metric Ton KG G Pound L ML

Send

Send