(S)-3-benzyloxy-4-((4R,6R)-6-ethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-2,2-dimethyl-butan-1-ol

Base Information

Chemical Name:(S)-3-benzyloxy-4-((4R,6R)-6-ethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-2,2-dimethyl-butan-1-ol
CAS No.:1262295-47-5
Molecular Formula:C₂₁H₃₄O₄
Molecular Weight:350.499
Hs Code.:

Synonyms:(S)-3-benzyloxy-4-((4R,6R)-6-ethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-2,2-dimethyl-butan-1-ol

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Chemical Property of (S)-3-benzyloxy-4-((4R,6R)-6-ethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-2,2-dimethyl-butan-1-ol

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Technology Process of (S)-3-benzyloxy-4-((4R,6R)-6-ethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-2,2-dimethyl-butan-1-ol

There total 11 articles about (S)-3-benzyloxy-4-((4R,6R)-6-ethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-2,2-dimethyl-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1262295-46-4
[(S)-3-benzyloxy-4-((4R,6R)-6-ethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-2,2-dimethyl-butoxy]-tert-butyl-dimethyl-silane

: 1262295-47-5
(S)-3-benzyloxy-4-((4R,6R)-6-ethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-2,2-dimethyl-butan-1-ol

Guidance literature:: [(S)-3-benzyloxy-4-((4R,6R)-6-ethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-2,2-dimethyl-butoxy]-tert-butyl-dimethyl-silane; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 - 60 ℃; for 3h; Inert atmosphere;

With water; In tetrahydrofuran; Inert atmosphere;
DOI:10.1021/jo101782q

Reference yield:

: 1262295-45-3
(3R,5R,7S)-7-benzyloxy-9-(tert-butyl-dimethyl-silanyloxy)-8,8-dimethyl-nonane-3,5-diol

: 1262295-47-5
(S)-3-benzyloxy-4-((4R,6R)-6-ethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-2,2-dimethyl-butan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 3 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 - 60 °C / Inert atmosphere

2.2: Inert atmosphere

With tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo101782q

Reference yield:

: 1262295-44-2
(5S,7S)-7-benzyloxy-9-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-8,8-dimethyl-nonan-3-one

: 1262295-47-5
(S)-3-benzyloxy-4-((4R,6R)-6-ethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-2,2-dimethyl-butan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; tetramethylammonium triacetoxyborohydride / acetonitrile / 14 h / -40 - 20 °C / Inert atmosphere

2.1: pyridinium p-toluenesulfonate / dichloromethane / 3 h / 20 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 - 60 °C / Inert atmosphere

3.2: Inert atmosphere

With tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; acetic acid; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo101782q