N-(2,3,6-trifluorobenzyl)-3-(1-(benzylamino)-2-methyl-1-oxopropan-2-yl)-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-6-carboxamide

Base Information

Chemical Name:N-(2,3,6-trifluorobenzyl)-3-(1-(benzylamino)-2-methyl-1-oxopropan-2-yl)-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-6-carboxamide
CAS No.:1622400-79-6
Molecular Formula:C₂₈H₂₅F₃N₄O₄
Molecular Weight:538.526
Hs Code.:

Synonyms:N-(2,3,6-trifluorobenzyl)-3-(1-(benzylamino)-2-methyl-1-oxopropan-2-yl)-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-6-carboxamide

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Chemical Property of N-(2,3,6-trifluorobenzyl)-3-(1-(benzylamino)-2-methyl-1-oxopropan-2-yl)-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-6-carboxamide

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Technology Process of N-(2,3,6-trifluorobenzyl)-3-(1-(benzylamino)-2-methyl-1-oxopropan-2-yl)-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-6-carboxamide

There total 4 articles about N-(2,3,6-trifluorobenzyl)-3-(1-(benzylamino)-2-methyl-1-oxopropan-2-yl)-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 2033-24-1
cycl-isopropylidene malonate

: 88333-03-3,10340-91-7
Benzyl isocyanide

: 1622400-61-6
C₁₄H₁₂F₃N₃O

: 1622400-79-6
N-(2,3,6-trifluorobenzyl)-3-(1-(benzylamino)-2-methyl-1-oxopropan-2-yl)-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-6-carboxamide

Guidance literature:: In 1,2-dichloro-ethane; Inert atmosphere; Reflux;
DOI:10.1016/j.bmcl.2014.06.041

Reference yield:

: 1622400-44-5
2-amino-N-(2,3,6-trifluorobenzyl)-3-nitrobenzamide

: 1622400-79-6
N-(2,3,6-trifluorobenzyl)-3-(1-(benzylamino)-2-methyl-1-oxopropan-2-yl)-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-6-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 15% palladium on carbon / methanol

2: 1,2-dichloro-ethane / Inert atmosphere; Reflux

With 15% palladium on carbon; In methanol; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2014.06.041

Reference yield:

: 606-18-8
3-nitroanthranilic acid

: 1622400-79-6
N-(2,3,6-trifluorobenzyl)-3-(1-(benzylamino)-2-methyl-1-oxopropan-2-yl)-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-6-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.08 h / 20 °C

1.2: 20 °C

2.1: 15% palladium on carbon / methanol

3.1: 1,2-dichloro-ethane / Inert atmosphere; Reflux

With 15% palladium on carbon; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2014.06.041