(5-bromo-2-methylphenyl)(5-(pyridin-3-yl)thiophen-2-yl)methanol

Base Information

• Chemical Name: (5-bromo-2-methylphenyl)(5-(pyridin-3-yl)thiophen-2-yl)methanol
• CAS No.: 1450738-08-5
• Molecular Formula: C₁₇H₁₄BrNOS
• Molecular Weight: 360.274
• Mol file: 1450738-08-5.mol

Synonyms:(5-bromo-2-methylphenyl)(5-(pyridin-3-yl)thiophen-2-yl)methanol

Chemical Property of (5-bromo-2-methylphenyl)(5-(pyridin-3-yl)thiophen-2-yl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5-bromo-2-methylphenyl)(5-(pyridin-3-yl)thiophen-2-yl)methanol

There total 1 articles about (5-bromo-2-methylphenyl)(5-(pyridin-3-yl)thiophen-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

5-bromo-2-methylbenzaldehyde (90050-59-2) + 3-thiophen-2-yl-pyridine (21298-53-3) → (5-bromo-2-methylphenyl)(5-(pyridin-3-yl)thiophen-2-yl)methanol (1450738-08-5)

Guidance literature:

3-thiophen-2-yl-pyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; Inert atmosphere;

5-bromo-2-methylbenzaldehyde; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmc.2013.05.048

Reference yield: 100.0%

(5-bromo-2-methylphenyl)(5-(pyridin-3-yl)thiophen-2-yl)methanol (1450738-08-5) → 3-[5-(5-bromo-2-methylbenzyl)thiophen-2-yl]pyridine (842136-42-9)

Guidance literature:

With sodium tris(acetoxy)borohydride; trifluoroacetic acid; at 0 - 20 ℃; for 1.58333h; Inert atmosphere;

DOI:10.1016/j.bmc.2013.05.048

Reference yield:

(5-bromo-2-methylphenyl)(5-(pyridin-3-yl)thiophen-2-yl)methanol (1450738-08-5) → C35H57NO6SSi4

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid; sodium tris(acetoxy)borohydride / 1.58 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / toluene; hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 °C / Inert atmosphere

With n-butyllithium; sodium tris(acetoxy)borohydride; trifluoroacetic acid; In tetrahydrofuran; hexane; toluene; 2.2: |Barbier Coupling Reaction;

DOI:10.1016/j.bmc.2013.05.048

upstream raw materials:

5-bromo-2-methylbenzaldehyde

3-thiophen-2-yl-pyridine

Downstream raw materials:

3-[5-(5-bromo-2-methylbenzyl)thiophen-2-yl]pyridine

1-(β-D-glucopyranosyl)-4-methyl-3-[(5-(3-pyridyl)-2-thienyl)methyl]benzene

1-(1-methoxy-D-glucopyranosyl)-4-methyl-3-[(5-(3-pyridyl)-2-thienyl)methyl]benzene