2-O-acetyl-3,5-di-O-benzoyl-β-D-xylofuranosyl-5-iodouracil

Base Information

• Chemical Name: 2-O-acetyl-3,5-di-O-benzoyl-β-D-xylofuranosyl-5-iodouracil
• CAS No.: 145693-68-1
• Molecular Formula: C₂₅H₂₁IN₂O₉
• Molecular Weight: 620.354
• Mol file: 145693-68-1.mol

Synonyms:2-O-acetyl-3,5-di-O-benzoyl-β-D-xylofuranosyl-5-iodouracil

Chemical Property of 2-O-acetyl-3,5-di-O-benzoyl-β-D-xylofuranosyl-5-iodouracil

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-O-acetyl-3,5-di-O-benzoyl-β-D-xylofuranosyl-5-iodouracil

There total 1 articles about 2-O-acetyl-3,5-di-O-benzoyl-β-D-xylofuranosyl-5-iodouracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5-iodo-2,4-bis-O-trimethylsilyluracil (38953-72-9) + (3R,4S,5R)-4-(benzoyloxy)-5-((benzoyloxy)methyl)tetrahydrofuran-2,3-diyl diacetate (85026-60-4) → 2-O-acetyl-3,5-di-O-benzoyl-β-D-xylofuranosyl-5-iodouracil (145693-68-1)

Guidance literature:

With tin(IV) chloride; In 1,2-dichloro-ethane; at 20 ℃; for 6h;

DOI:10.1007/BF00704207

Reference yield: 82.0%

phenylacetylene (536-74-3) + 2-O-acetyl-3,5-di-O-benzoyl-β-D-xylofuranosyl-5-iodouracil (145693-68-1) → 6-phenyl-3-(2-O-acetyl-3,5-di-O-benzoyl-β-D-xylofuranosyl)furano<2,3-d>pyrimidin-2-one (145693-69-2)

Guidance literature:

With copper(l) iodide; triethylamine; triphenylphosphine; palladium on activated charcoal; In acetonitrile; for 5h; Product distribution; interaction 5-iodo- and 5-bromouracil derivatives with terminal alkynes in the presence of catalytic amounts of Pd/C and CuI;

DOI:10.1007/BF00698454

Reference yield: 81.0%

1-decyne (764-93-2) + 2-O-acetyl-3,5-di-O-benzoyl-β-D-xylofuranosyl-5-iodouracil (145693-68-1) → 3-(2-O-acetyl-3,5-di-O-benzoyl-β-D-xylofuranosyl)-6-octylfuro<2,3-d>pyrimidine-2-one

Guidance literature:

With copper(l) iodide; triethylamine; palladium on activated charcoal; In acetonitrile; for 6h;

DOI:10.1007/BF00698454

upstream raw materials:

5-iodo-2,4-bis-O-trimethylsilyluracil

(3R,4S,5R)-4-(benzoyloxy)-5-((benzoyloxy)methyl)tetrahydrofuran-2,3-diyl diacetate

Downstream raw materials:

3-(3,5-di-O-benzoyl-β-D-xylofuranosyl)-6-hydroxymethylfuro<2,3-d>pyrimidine-2-one

6-phenyl-3-(2-O-acetyl-3,5-di-O-benzoyl-β-D-xylofuranosyl)furano<2,3-d>pyrimidin-2-one

C₂₃H₁₉IN₂O₈

C₂₃H₁₇IN₂O₇