N-methyl-4-[3-(methyloxy)-1-piperidinyl]-3-(1H-purin-6-ylamino)benzenesulfonamide

Base Information

Chemical Name:N-methyl-4-[3-(methyloxy)-1-piperidinyl]-3-(1H-purin-6-ylamino)benzenesulfonamide
CAS No.:1351089-33-2
Molecular Formula:C₁₈H₂₃N₇O₃S
Molecular Weight:417.492
Hs Code.:

Synonyms:N-methyl-4-[3-(methyloxy)-1-piperidinyl]-3-(1H-purin-6-ylamino)benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-methyl-4-[3-(methyloxy)-1-piperidinyl]-3-(1H-purin-6-ylamino)benzenesulfonamide

Chemical Property:

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Technology Process of N-methyl-4-[3-(methyloxy)-1-piperidinyl]-3-(1H-purin-6-ylamino)benzenesulfonamide

There total 7 articles about N-methyl-4-[3-(methyloxy)-1-piperidinyl]-3-(1H-purin-6-ylamino)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1351094-51-3
3-amino-N-methyl-4-[3-(methyloxy)-1-piperidinyl]benzenesulfonamide

: 87-42-3
6-chloropurine

: 1351089-33-2
N-methyl-4-[3-(methyloxy)-1-piperidinyl]-3-(1H-purin-6-ylamino)benzenesulfonamide

Guidance literature:: With acetic acid; at 110 ℃; for 20h; Sealed tube;

Reference yield:

: 6859-99-0
3-hydroxypiperazine

: 1351089-33-2
N-methyl-4-[3-(methyloxy)-1-piperidinyl]-3-(1H-purin-6-ylamino)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: t-butyl malonate / acetonitrile / 20 h

1.2: 20.5 h / 0 - 25 °C

1.3: 20 h / 25 °C

2.1: triethylamine / 20 h / 110 °C / Sealed vessel

3.1: hydrogen / palladium on activated charcoal / ethanol / 0.75 h / 1810.07 Torr

4.1: acetic acid / 20 h / 110 °C / Sealed tube

With t-butyl malonate; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In ethanol; acetonitrile;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1351089-33-2
N-methyl-4-[3-(methyloxy)-1-piperidinyl]-3-(1H-purin-6-ylamino)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: chlorosulfonic acid / 18 h / 100 °C

2: triethylamine / tetrahydrofuran / 1 h / -35 °C

3: triethylamine / 20 h / 110 °C / Sealed vessel

4: hydrogen / palladium on activated charcoal / ethanol / 0.75 h / 1810.07 Torr

5: acetic acid / 20 h / 110 °C / Sealed tube

With chlorosulfonic acid; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol;