3-Isoxazolecarboxaldehyde, 4,5-dihydro-4-methyl-5-(1-methylethyl)-, (4S,5R)- (9CI)

Base Information

Chemical Name:3-Isoxazolecarboxaldehyde, 4,5-dihydro-4-methyl-5-(1-methylethyl)-, (4S,5R)- (9CI)
CAS No.:735317-46-1
Molecular Formula:C8H13 N O2
Molecular Weight:155.19432
Hs Code.:
Mol file:735317-46-1.mol

Synonyms:3-Isoxazolecarboxaldehyde, 4,5-dihydro-4-methyl-5-(1-methylethyl)-, (4S,5R)- (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Isoxazolecarboxaldehyde, 4,5-dihydro-4-methyl-5-(1-methylethyl)-, (4S,5R)- (9CI)

Chemical Property:

PSA：38.66000
LogP:0.66780

Purity/Quality:

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Hazard Codes:

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Technology Process of 3-Isoxazolecarboxaldehyde, 4,5-dihydro-4-methyl-5-(1-methylethyl)-, (4S,5R)- (9CI)

There total 1 articles about 3-Isoxazolecarboxaldehyde, 4,5-dihydro-4-methyl-5-(1-methylethyl)-, (4S,5R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 735317-70-1
((4S,5R)-5-Isopropyl-4-methyl-4,5-dihydro-isoxazol-3-yl)-methanol

: 735317-46-1
(4S,5R)-5-Isopropyl-4-methyl-4,5-dihydro-isoxazole-3-carbaldehyde

Guidance literature:: With silica gel; pyridinium chlorochromate; In dichloromethane; for 3h;
DOI:10.1021/ol0490633

Reference yield: 75.0%

: 735317-46-1
(4S,5R)-5-Isopropyl-4-methyl-4,5-dihydro-isoxazole-3-carbaldehyde

: 735317-48-3
5-((R)-2-{(4S,5R)-5-[(R)-1-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methyl-4,5-dihydro-isoxazol-3-yl}-propane-1-sulfonyl)-1-phenyl-1H-tetrazole

: 735317-50-7
C₃₃H₄₆N₂O₃Si

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; at -78 - 20 ℃; for 2h;
DOI:10.1021/ol0490633

Reference yield:

: 735317-46-1
(4S,5R)-5-Isopropyl-4-methyl-4,5-dihydro-isoxazole-3-carbaldehyde

: 735317-72-3
C₃₃H₄₈N₂O₃Si

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / KHMDS / tetrahydrofuran / 2 h / -78 - 20 °C

2: 96 percent / H₂ / Pd/C / ethanol / 2.5 h

With hydrogen; potassium hexamethylsilazane; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/ol0490633