di-tert-butyl N-{4-[4-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-1-formyl-but-2-yl]benzoyl}-L-glutamate

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Chemical Name:di-tert-butyl N-{4-[4-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-1-formyl-but-2-yl]benzoyl}-L-glutamate
CAS No.:485389-65-9
Molecular Formula:C₂₉H₄₁N₅O₇
Molecular Weight:571.674
Hs Code.:

Synonyms:di-tert-butyl N-{4-[4-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-1-formyl-but-2-yl]benzoyl}-L-glutamate

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Chemical Property of di-tert-butyl N-{4-[4-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-1-formyl-but-2-yl]benzoyl}-L-glutamate

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Technology Process of di-tert-butyl N-{4-[4-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-1-formyl-but-2-yl]benzoyl}-L-glutamate

There total 7 articles about di-tert-butyl N-{4-[4-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-1-formyl-but-2-yl]benzoyl}-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: di-tert-butyl N-{4-[5-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-1-(dimethylhydrazono)pent-2-yl]benzoyl}-L-glutamate

: 485389-65-9
di-tert-butyl N-{4-[4-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-1-formyl-but-2-yl]benzoyl}-L-glutamate

: 485389-66-0
di-tert-butyl N-{4-[4-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-1-oxo-but-1-yl]benzoyl}-L-glutamate

Guidance literature:: With copper dichloride; In phosphate buffer; at 0 ℃; for 1h; pH=7;
DOI:10.1016/S0968-0896(02)00102-5

Reference yield:

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

: 485389-65-9
di-tert-butyl N-{4-[4-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-1-formyl-but-2-yl]benzoyl}-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 36 percent / NaHCO₃; EDCI / dimethylformamide / 12 h / 25 °C

2: 39 percent / aq. CuCl₂ / aq. phosphate buffer / 1 h / 0 °C / pH 7

With sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; copper dichloride; In phosphate buffer; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00102-5

Reference yield:

: 4-[2-(dimethyl-hydrazono)-ethyl]-benzoic acid methyl ester

: 485389-65-9
di-tert-butyl N-{4-[4-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-1-formyl-but-2-yl]benzoyl}-L-glutamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

1.2: 52 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 2 h / -78 °C

2.1: NaH / dimethylformamide / 0.5 h / 0 °C

2.2: dimethylformamide / 2.5 h / 25 °C

3.1: Na / methanol / 0.5 h / 25 °C

3.2: 52 percent / methanol / 12 h / 25 °C

4.1: 88 percent / aq. LiOH / methanol; H₂O / 12 h / 25 °C

5.1: 36 percent / NaHCO₃; EDCI / dimethylformamide / 12 h / 25 °C

6.1: 39 percent / aq. CuCl₂ / aq. phosphate buffer / 1 h / 0 °C / pH 7

With lithium hydroxide; sodium; sodium hydride; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; copper dichloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; phosphate buffer; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00102-5