[2-(4-benzyl-2-oxo-oxazolidin-3-yl)-1-(3,5-bisisopropyloxy-4-methoxy-phenyl)-2-oxo-ethyl]carbamic acid tert-butyl ester

Base Information

Chemical Name:[2-(4-benzyl-2-oxo-oxazolidin-3-yl)-1-(3,5-bisisopropyloxy-4-methoxy-phenyl)-2-oxo-ethyl]carbamic acid tert-butyl ester
CAS No.:217494-28-5
Molecular Formula:C₃₀H₄₀N₂O₈
Molecular Weight:556.656
Hs Code.:

Synonyms:[2-(4-benzyl-2-oxo-oxazolidin-3-yl)-1-(3,5-bisisopropyloxy-4-methoxy-phenyl)-2-oxo-ethyl]carbamic acid tert-butyl ester

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Chemical Property of [2-(4-benzyl-2-oxo-oxazolidin-3-yl)-1-(3,5-bisisopropyloxy-4-methoxy-phenyl)-2-oxo-ethyl]carbamic acid tert-butyl ester

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Technology Process of [2-(4-benzyl-2-oxo-oxazolidin-3-yl)-1-(3,5-bisisopropyloxy-4-methoxy-phenyl)-2-oxo-ethyl]carbamic acid tert-butyl ester

There total 11 articles about [2-(4-benzyl-2-oxo-oxazolidin-3-yl)-1-(3,5-bisisopropyloxy-4-methoxy-phenyl)-2-oxo-ethyl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 178744-37-1
(R)-3-[(R)-2-Azido-2-(3,5-diisopropoxy-4-methoxy-phenyl)-acetyl]-4-benzyl-oxazolidin-2-one

: 217494-28-5
[2-(4-benzyl-2-oxo-oxazolidin-3-yl)-1-(3,5-bisisopropyloxy-4-methoxy-phenyl)-2-oxo-ethyl]carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 4h; under 760 Torr;
DOI:10.1016/S0957-4166(98)00312-7

Reference yield:

: 918446-55-6
(3,5-Diisopropoxy-4-methoxy-phenyl)-methanol

: 217494-28-5
[2-(4-benzyl-2-oxo-oxazolidin-3-yl)-1-(3,5-bisisopropyloxy-4-methoxy-phenyl)-2-oxo-ethyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / PBr₃ / toluene

2: 97 percent / dimethylsulfoxide

3: 94 percent / K₂CO₃, H₂O₂ / dimethylsulfoxide

4: 88 percent / KOH / ethane-1,2-diol

5: Et₃N / tetrahydrofuran / 1 h / -78 - 0 °C

6: tetrahydrofuran; hexane / 1.) -78 deg C, 15 min, 2.) from -78 deg C to RT, 30 min

7: 1.) KHMDS, 2.) trisisopropylbenzenesulfonylazide, 3.) NaI, KOAc

8: 85 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h / 760 Torr

With potassium hydroxide; triisopropylbenzenesulfonyl azide; hydrogen; dihydrogen peroxide; potassium acetate; phosphorus tribromide; potassium hexamethylsilazane; potassium carbonate; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; hexane; ethylene glycol; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1016/S0957-4166(98)00312-7

Reference yield:

: 918446-56-7
5-Bromomethyl-1,3-diisopropoxy-2-methoxy-benzene

: 217494-28-5
[2-(4-benzyl-2-oxo-oxazolidin-3-yl)-1-(3,5-bisisopropyloxy-4-methoxy-phenyl)-2-oxo-ethyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / dimethylsulfoxide

2: 94 percent / K₂CO₃, H₂O₂ / dimethylsulfoxide

3: 88 percent / KOH / ethane-1,2-diol

4: Et₃N / tetrahydrofuran / 1 h / -78 - 0 °C

5: tetrahydrofuran; hexane / 1.) -78 deg C, 15 min, 2.) from -78 deg C to RT, 30 min

6: 1.) KHMDS, 2.) trisisopropylbenzenesulfonylazide, 3.) NaI, KOAc

7: 85 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h / 760 Torr

With potassium hydroxide; triisopropylbenzenesulfonyl azide; hydrogen; dihydrogen peroxide; potassium acetate; potassium hexamethylsilazane; potassium carbonate; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; hexane; ethylene glycol; dimethyl sulfoxide; ethyl acetate;
DOI:10.1016/S0957-4166(98)00312-7