4-(diethoxyphosphoryl)-1,7,10-tris(p-tolylsulfonyl)-1,4,7,10-tetraazacyclotridecane

Base Information

• Chemical Name: 4-(diethoxyphosphoryl)-1,7,10-tris(p-tolylsulfonyl)-1,4,7,10-tetraazacyclotridecane
• CAS No.: 166303-09-9
• Molecular Formula: C₃₄H₄₉N₄O₉PS₃
• Molecular Weight: 784.956

Synonyms:4-(diethoxyphosphoryl)-1,7,10-tris(p-tolylsulfonyl)-1,4,7,10-tetraazacyclotridecane

Chemical Property of 4-(diethoxyphosphoryl)-1,7,10-tris(p-tolylsulfonyl)-1,4,7,10-tetraazacyclotridecane

Chemical Property:

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Technology Process of 4-(diethoxyphosphoryl)-1,7,10-tris(p-tolylsulfonyl)-1,4,7,10-tetraazacyclotridecane

There total 2 articles about 4-(diethoxyphosphoryl)-1,7,10-tris(p-tolylsulfonyl)-1,4,7,10-tetraazacyclotridecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

tris(p-tolylsulfonyl)-N-(2-aminoethyl)-1,3-propanediamine (35980-63-3) + N-(diethoxyphosphoryl)-O,O'-bis(2-methylsulfonyl)di-ethanolamine (166303-07-7) → 4-(diethoxyphosphoryl)-1,7,10-tris(p-tolylsulfonyl)-1,4,7,10-tetraazacyclotridecane (166303-09-9)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 55 ℃; for 30h;

DOI:10.1021/jm00002a019

Reference yield:

bis-(2-hydroxy-ethyl)-amidophosphoric acid diethyl ester (2359-07-1) → 4-(diethoxyphosphoryl)-1,7,10-tris(p-tolylsulfonyl)-1,4,7,10-tetraazacyclotridecane (166303-09-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / Et₃N / CH₂Cl₂ / Ambient temperature

2: 55 percent / Cs₂CO₃ / dimethylformamide / 30 h / 55 °C

With caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00002a019

Reference yield: 76.0%

4-(diethoxyphosphoryl)-1,7,10-tris(p-tolylsulfonyl)-1,4,7,10-tetraazacyclotridecane (166303-09-9) → 1,7,10-tris(p-tolylsulfonyl)-1,4,7,10-tetraazacyclotridecane (166303-11-3)

Guidance literature:

With hydrogen bromide; acetic acid; for 2.5h; Ambient temperature;

DOI:10.1021/jm00002a019

upstream raw materials:

tris(p-tolylsulfonyl)-N-(2-aminoethyl)-1,3-propanediamine

N-(diethoxyphosphoryl)-O,O'-bis(2-methylsulfonyl)di-ethanolamine

bis-(2-hydroxy-ethyl)-amidophosphoric acid diethyl ester

Downstream raw materials:

1,7,10-tris(p-tolylsulfonyl)-1,4,7,10-tetraazacyclotridecane

C₆₈H₈₆N₈O₁₂S₆

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