1-(2,4-dihydroxy-5-isopropyl-phenyl)-5-(4-piperidin-1-ylmethyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

Base Information

• Chemical Name: 1-(2,4-dihydroxy-5-isopropyl-phenyl)-5-(4-piperidin-1-ylmethyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide
• CAS No.: 1383717-32-5
• Molecular Formula: C₂₆H₃₃N₅O₃
• Molecular Weight: 463.58
• Mol file: 1383717-32-5.mol

Synonyms:1-(2,4-dihydroxy-5-isopropyl-phenyl)-5-(4-piperidin-1-ylmethyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

Chemical Property of 1-(2,4-dihydroxy-5-isopropyl-phenyl)-5-(4-piperidin-1-ylmethyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,4-dihydroxy-5-isopropyl-phenyl)-5-(4-piperidin-1-ylmethyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

There total 16 articles about 1-(2,4-dihydroxy-5-isopropyl-phenyl)-5-(4-piperidin-1-ylmethyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

→ 1-(2,4-dihydroxy-5-isopropyl-phenyl)-5-(4-piperidin-1-ylmethyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide (1383717-32-5)

Guidance literature:

Reference yield:

C40H45N5O3 → 1-(2,4-dihydroxy-5-isopropyl-phenyl)-5-(4-piperidin-1-ylmethyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide (1383717-32-5)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In ethanol; at 20 ℃; for 4h; under 760.051 Torr; Sealed tube;

DOI:10.1021/jm401536b

Reference yield:

2,4-bis-(benzyloxy)-5-isopropylaniline (1383717-80-3) → 1-(2,4-dihydroxy-5-isopropyl-phenyl)-5-(4-piperidin-1-ylmethyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide (1383717-32-5)

Guidance literature:

Multi-step reaction with 7 steps

1: tert.-butylnitrite; trimethylsilylazide / acetonitrile / 13 h / 0 - 20 °C

2: chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer / N,N-dimethyl-formamide / 12 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4: triethylamine / dichloromethane / 12.5 h / 0 - 20 °C

5: triethylamine / N,N-dimethyl-formamide / 20 °C

6: methanol / 48 h / 80 °C / Sealed tube

7: hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol / 4 h / 20 °C / 760.05 Torr / Sealed tube

With tert.-butylnitrite; chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer; trimethylsilylazide; 10 wt% Pd(OH)2 on carbon; tetrabutyl ammonium fluoride; hydrogen; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 2: |Huisgen Cycloaddition;

DOI:10.1021/jm401536b

upstream raw materials:

2,4-bis-(benzyloxy)-5-isopropylaniline

tert-butyl[(4-ethynylphenyl)methoxy]dimethylsilane

methyl 3-(4-((tert-butyldimethylsilyloxy)methyl)phenyl)-prop-2-ynoate

methyl 1-[2,4-bis(benzyloxy)cumenyl]-5-[p-(tert-butyldimethylsilyloxymethyl)phenyl]-1H-1,2,3-triazole-4-carboxylate