3-oximino-5-phenyl-1-(2,2,2-trifluoroethyl)-1H-benzo<1,4>diazepine

Base Information

• Chemical Name: 3-oximino-5-phenyl-1-(2,2,2-trifluoroethyl)-1H-benzo<1,4>diazepine
• CAS No.: 220892-17-1
• Molecular Formula: C₁₇H₁₂F₃N₃O₂
• Molecular Weight: 347.296
• Mol file: 220892-17-1.mol

Synonyms:3-oximino-5-phenyl-1-(2,2,2-trifluoroethyl)-1H-benzo<1,4>diazepine

Chemical Property of 3-oximino-5-phenyl-1-(2,2,2-trifluoroethyl)-1H-benzo<1,4>diazepine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-oximino-5-phenyl-1-(2,2,2-trifluoroethyl)-1H-benzo<1,4>diazepine

There total 1 articles about 3-oximino-5-phenyl-1-(2,2,2-trifluoroethyl)-1H-benzo<1,4>diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dihydro-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-1H-benzo[e][1,4]diazepine (23199-54-4) → 3-oximino-5-phenyl-1-(2,2,2-trifluoroethyl)-1H-benzo<1,4>diazepine (220892-17-1)

Guidance literature:

With tert.-butylnitrite; potassium tert-butylate; In tetrahydrofuran; toluene; at -40 ℃; for 5h; Yield given; other reagent: potassium t-butoxide/isoamyl nitrite;

DOI:10.1016/S0040-4020(98)01098-9

Reference yield: 90.0%

3-oximino-5-phenyl-1-(2,2,2-trifluoroethyl)-1H-benzo<1,4>diazepine (220892-17-1) → 3-amino-5-phenyl-1-(2,2,2-trifluoroethyl)-1H-benzo<1,4>diazepine (177954-78-8)

Guidance literature:

With hydrogen; pyrographite; ruthenium; In methanol; at 70 ℃; for 3h; under 2068.59 Torr;

DOI:10.1016/S0040-4020(98)01098-9

Reference yield:

(R)-Mandelic Acid (611-71-2) + 3-oximino-5-phenyl-1-(2,2,2-trifluoroethyl)-1H-benzo<1,4>diazepine (220892-17-1) → 3R-(+)-3-amino-5-phenyl-1-(2,2,2-trifluoroethyl)-1H-benzo<1,4>diazepine-(R)-(-)-mandelate

Guidance literature:

With hydrogen; 3,5-dichlorosalicyclaldehyde; pyrographite; ruthenium; Yield given; Multistep reaction; 1.) methanol, 70 deg C, 40 psi, 3 h, 2.) isopropyl acetate, water, room temperature, 20 h;

DOI:10.1016/S0040-4020(98)01098-9

upstream raw materials:

2,3-dihydro-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-1H-benzo[e][1,4]diazepine

Downstream raw materials:

3-amino-5-phenyl-1-(2,2,2-trifluoroethyl)-1H-benzo<1,4>diazepine