Technology Process of 2-[(5-methoxy-1,3-benzothiazol-2-yl)methyl]-1H-isoindole-1,3(2H)-dione
There total 1 articles about 2-[(5-methoxy-1,3-benzothiazol-2-yl)methyl]-1H-isoindole-1,3(2H)-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
phthalic anhydride; (5-methoxybenzothiazol-2-yl)methylamine hydrogen chloride;
With
N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at 70 ℃;
for 4.66667h;
Cooling with ice;
Inert atmosphere;
With
hydrogenchloride;
In
tetrahydrofuran; diethyl ether; water;
With
toluene-4-sulfonic acid;
In
toluene;
at 115 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere
2: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 72 h / 0 - 20 °C / Inert atmosphere
3: methylhydrazine / ethanol / 1.5 h / 80 °C / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine / acetonitrile / 72 h / 85 °C / Inert atmosphere
5: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 0 - 20 °C / Inert atmosphere
With
hydrogenchloride; boron tribromide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; methylhydrazine; diethylazodicarboxylate;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; acetonitrile;
2: |Mitsunobu Displacement;
DOI:10.1021/jm301499r
- Guidance literature:
-
Multi-step reaction with 7 steps
1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere
2: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 72 h / 0 - 20 °C / Inert atmosphere
3: methylhydrazine / ethanol / 1.5 h / 80 °C / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine / acetonitrile / 72 h / 85 °C / Inert atmosphere
5: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 0 - 20 °C / Inert atmosphere
6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane; tetrahydrofuran / 20 - 50 °C / Inert atmosphere
7: hydrogenchloride / tetrahydrofuran; 1,4-dioxane; methanol / 0 - 20 °C / Inert atmosphere
With
hydrogenchloride; dmap; boron tribromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; methylhydrazine; diethylazodicarboxylate;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; acetonitrile;
2: |Mitsunobu Displacement;
DOI:10.1021/jm301499r
