2-{[4-(tricyclo[3.3.1.1^3,7]dec-1-yl)quinolin-2-yl]carbonyl}-N-[4-(trifluoromethoxyphenyl)]hydrazinecarbothioamide

Base Information

• Chemical Name: 2-{[4-(tricyclo[3.3.1.1^3,7]dec-1-yl)quinolin-2-yl]carbonyl}-N-[4-(trifluoromethoxyphenyl)]hydrazinecarbothioamide
• CAS No.: 1621608-27-2
• Molecular Formula: C₂₈H₂₇F₃N₄O₂S
• Molecular Weight: 540.609

Synonyms:2-{[4-(tricyclo[3.3.1.1^3,7]dec-1-yl)quinolin-2-yl]carbonyl}-N-[4-(trifluoromethoxyphenyl)]hydrazinecarbothioamide

Chemical Property of 2-{[4-(tricyclo[3.3.1.1^3,7]dec-1-yl)quinolin-2-yl]carbonyl}-N-[4-(trifluoromethoxyphenyl)]hydrazinecarbothioamide

Chemical Property:

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Technology Process of 2-{[4-(tricyclo[3.3.1.1^3,7]dec-1-yl)quinolin-2-yl]carbonyl}-N-[4-(trifluoromethoxyphenyl)]hydrazinecarbothioamide

There total 2 articles about 2-{[4-(tricyclo[3.3.1.1^3,7]dec-1-yl)quinolin-2-yl]carbonyl}-N-[4-(trifluoromethoxyphenyl)]hydrazinecarbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-(adamantan-1-yl)-2-quinolinecarbohydrazide (824935-09-3) + 1-isothiocyanato-4-(trifluoromethoxy)benzene (64285-95-6) → 2-{[4-(tricyclo[3.3.1.13,7]dec-1-yl)quinolin-2-yl]carbonyl}-N-[4-(trifluoromethoxyphenyl)]hydrazinecarbothioamide (1621608-27-2)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2014.07.100

Reference yield:

methyl 4-(adamantan-1-yl)quinoline-2-carboxylate (753487-64-8) → 2-{[4-(tricyclo[3.3.1.13,7]dec-1-yl)quinolin-2-yl]carbonyl}-N-[4-(trifluoromethoxyphenyl)]hydrazinecarbothioamide (1621608-27-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / 8 h / 70 °C

2: tetrahydrofuran / 4 h / 20 °C

With hydrazine hydrate; In tetrahydrofuran; methanol;

DOI:10.1016/j.ejmech.2014.07.100

upstream raw materials:

methyl 4-(adamantan-1-yl)quinoline-2-carboxylate

4-(adamantan-1-yl)-2-quinolinecarbohydrazide

1-isothiocyanato-4-(trifluoromethoxy)benzene

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