4-(1-(3,5-dimethylphenylsulfonyl)-1H-indazol-3-yl)-3-fluorobenzoic acid

Base Information

Chemical Name:4-(1-(3,5-dimethylphenylsulfonyl)-1H-indazol-3-yl)-3-fluorobenzoic acid
CAS No.:1392809-29-8
Molecular Formula:C₂₂H₁₇FN₂O₄S
Molecular Weight:424.452
Hs Code.:

Synonyms:4-(1-(3,5-dimethylphenylsulfonyl)-1H-indazol-3-yl)-3-fluorobenzoic acid

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Chemical Property of 4-(1-(3,5-dimethylphenylsulfonyl)-1H-indazol-3-yl)-3-fluorobenzoic acid

Chemical Property:

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Technology Process of 4-(1-(3,5-dimethylphenylsulfonyl)-1H-indazol-3-yl)-3-fluorobenzoic acid

There total 2 articles about 4-(1-(3,5-dimethylphenylsulfonyl)-1H-indazol-3-yl)-3-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 851335-07-4
2-fluoro 4-carboxy phenylboronic acid

: 1392809-40-3
3-bromo-1-(3,5-dimethylphenylsulfonyl)-1H-indazole

: 1392809-29-8
4-(1-(3,5-dimethylphenylsulfonyl)-1H-indazol-3-yl)-3-fluorobenzoic acid

Guidance literature:: With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In Dimethyl ether; water; at 100 ℃; for 0.5h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 2905-27-3
3,5-dimethyl-benzenesulfonyl chloride

: 40598-94-5
3-bromo-1H-indazole

: 1392809-29-8
4-(1-(3,5-dimethylphenylsulfonyl)-1H-indazol-3-yl)-3-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C

2: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / Dimethyl ether; water / 0.5 h / 100 °C / Microwave irradiation; Inert atmosphere

With sodium hydride; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In Dimethyl ether; water; N,N-dimethyl-formamide; mineral oil; 2: Suzuki-Miyaura reaction;