ethyl (2,2-dimethyl-5-benzyl-4-tetrahydropyranylidene)cyanacetate

Base Information

• Chemical Name: ethyl (2,2-dimethyl-5-benzyl-4-tetrahydropyranylidene)cyanacetate
• CAS No.: 120729-50-2
• Molecular Formula: C₁₉H₂₃NO₃
• Molecular Weight: 313.397
• Mol file: 120729-50-2.mol

Synonyms:ethyl (2,2-dimethyl-5-benzyl-4-tetrahydropyranylidene)cyanacetate

Chemical Property of ethyl (2,2-dimethyl-5-benzyl-4-tetrahydropyranylidene)cyanacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (2,2-dimethyl-5-benzyl-4-tetrahydropyranylidene)cyanacetate

There total 1 articles about ethyl (2,2-dimethyl-5-benzyl-4-tetrahydropyranylidene)cyanacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2,2-dimethyl-5-benzyl-4-tetrahydropyranone (100096-04-6) + ethyl 2-cyanoacetate (105-56-6) → ethyl (2,2-dimethyl-5-benzyl-4-tetrahydropyranylidene)cyanacetate (120729-50-2)

Guidance literature:

With ammonium acetate; In toluene; for 6h; Heating;

DOI:10.1007/BF00764464

Reference yield: 44.6%

ethyl (2,2-dimethyl-5-benzyl-4-tetrahydropyranylidene)cyanacetate (120729-50-2) → 3-Amino-2-(5-benzyl-2,2-dimethyl-tetrahydro-pyran-4-yl)-propan-1-ol (120729-53-5)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃;

DOI:10.1007/BF00764464

upstream raw materials:

2,2-dimethyl-5-benzyl-4-tetrahydropyranone

ethyl 2-cyanoacetate

Downstream raw materials:

3-Amino-2-(5-benzyl-2,2-dimethyl-tetrahydro-pyran-4-yl)-propan-1-ol