(1S,2R)-1-(2-Benzo[1,3]dioxol-5-yl-3,4,5-trimethoxy-phenyl)-2-methyl-but-3-en-1-ol

Base Information

Chemical Name:(1S,2R)-1-(2-Benzo[1,3]dioxol-5-yl-3,4,5-trimethoxy-phenyl)-2-methyl-but-3-en-1-ol
CAS No.:870283-65-1
Molecular Formula:C₂₁H₂₄O₆
Molecular Weight:372.418
Hs Code.:

Synonyms:(1S,2R)-1-(2-Benzo[1,3]dioxol-5-yl-3,4,5-trimethoxy-phenyl)-2-methyl-but-3-en-1-ol

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Chemical Property of (1S,2R)-1-(2-Benzo[1,3]dioxol-5-yl-3,4,5-trimethoxy-phenyl)-2-methyl-but-3-en-1-ol

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Technology Process of (1S,2R)-1-(2-Benzo[1,3]dioxol-5-yl-3,4,5-trimethoxy-phenyl)-2-methyl-but-3-en-1-ol

There total 6 articles about (1S,2R)-1-(2-Benzo[1,3]dioxol-5-yl-3,4,5-trimethoxy-phenyl)-2-methyl-but-3-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 870283-64-0
[(1S,2R)-1-(2-Benzo[1,3]dioxol-5-yl-3,4,5-trimethoxy-phenyl)-2-methyl-but-3-enyloxy]-tert-butyl-dimethyl-silane

: 870283-65-1
(1S,2R)-1-(2-Benzo[1,3]dioxol-5-yl-3,4,5-trimethoxy-phenyl)-2-methyl-but-3-en-1-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1021/jo0516234

Reference yield:

: 870283-69-5
(2S,3S)-3-(2-Benzo[1,3]dioxol-5-yl-3,4,5-trimethoxy-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propionaldehyde

: 870283-65-1
(1S,2R)-1-(2-Benzo[1,3]dioxol-5-yl-3,4,5-trimethoxy-phenyl)-2-methyl-but-3-en-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / 20 °C

1.2: 1.49 g / tetrahydrofuran; hexane / 12 h / 20 °C

2.1: 85 percent / n-Bu₄NF / tetrahydrofuran / 4 h / 20 °C

With n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; hexane; 1.2: Wittig reaction;
DOI:10.1021/jo0516234

Reference yield:

: 870283-63-9
(2R,3S)-3-(2-Benzo[1,3]dioxol-5-yl-3,4,5-trimethoxy-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propan-1-ol

: 870283-65-1
(1S,2R)-1-(2-Benzo[1,3]dioxol-5-yl-3,4,5-trimethoxy-phenyl)-2-methyl-but-3-en-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / Dess-Martin periodinane / CH₂Cl₂ / 1.5 h / 0 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 1 h / 20 °C

2.2: 1.49 g / tetrahydrofuran; hexane / 12 h / 20 °C

3.1: 85 percent / n-Bu₄NF / tetrahydrofuran / 4 h / 20 °C

With n-butyllithium; tetrabutyl ammonium fluoride; Dess-Martin periodane; In tetrahydrofuran; hexane; dichloromethane; 1.1: Dess-Martin oxidation / 2.2: Wittig reaction;
DOI:10.1021/jo0516234