5-[2,4-dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(piperidin-4-yl)isoxazole-3-carboxamide hydrochloride

Base Information

Chemical Name:5-[2,4-dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(piperidin-4-yl)isoxazole-3-carboxamide hydrochloride
CAS No.:1253584-63-2
Molecular Formula:C₂₁H₂₀N₄O₇*ClH
Molecular Weight:476.873
Hs Code.:

Synonyms:5-[2,4-dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(piperidin-4-yl)isoxazole-3-carboxamide hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[2,4-dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(piperidin-4-yl)isoxazole-3-carboxamide hydrochloride

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Technology Process of 5-[2,4-dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(piperidin-4-yl)isoxazole-3-carboxamide hydrochloride

There total 7 articles about 5-[2,4-dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(piperidin-4-yl)isoxazole-3-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: tert-butyl 4-[({5-[2,4-bis(methoxymethoxy)-6-(4-nitrophenoxy)phenyl]isoxazol-3-yl}carbonyl)amino]piperidine-1-carboxylate

: 1253584-63-2
5-[2,4-dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(piperidin-4-yl)isoxazole-3-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; ethanol; In 1,4-dioxane; at 20 ℃; for 5h;
DOI:10.1016/j.bmc.2013.09.018

Reference yield: 13.0%

: 1253584-63-2
5-[2,4-dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(piperidin-4-yl)isoxazole-3-carboxamide hydrochloride

Guidance literature:

Reference yield:

: 480-66-0,67471-34-5
2,4,6-trihydroxyacetophenone

: 1253584-63-2
5-[2,4-dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(piperidin-4-yl)isoxazole-3-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: zinc dibromide; acetyl chloride / dichloromethane / 3.5 h / 20 - 30 °C

1.2: 5 - 10 °C

2.1: potassium carbonate / dimethyl sulfoxide; water / 6.4 h / 20 - 55 °C

3.1: sodium t-butanolate / tetrahydrofuran / 3 h / -10 - 20 °C

4.1: sodium acetate; hydroxylamine hydrochloride / ethanol; tetrahydrofuran / 2 h / 20 °C

4.2: 24 h / pH 2

5.1: dichloromethane / 24 h / 80 °C

6.1: hydrogenchloride; ethanol / 1,4-dioxane / 5 h / 20 °C

With hydrogenchloride; ethanol; hydroxylamine hydrochloride; sodium acetate; potassium carbonate; acetyl chloride; zinc dibromide; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2013.09.018