5-Thiazolecarboxylicacid,2-amino-4-(methoxymethyl)-,methylester(9CI)

Base Information

• Chemical Name: 5-Thiazolecarboxylicacid,2-amino-4-(methoxymethyl)-,methylester(9CI)
• CAS No.: 733754-08-0
• Molecular Formula: C₇H₁₀N₂O₃S
• Molecular Weight: 202.234
• Hs Code.: 2934100090
• Mol file: 733754-08-0.mol

Synonyms:Methyl2-amino-4-(methoxymethyl)-1,3-thiazole-5-carboxylate

Chemical Property of 5-Thiazolecarboxylicacid,2-amino-4-(methoxymethyl)-,methylester(9CI)

Chemical Property:

• PSA: 102.68000
• LogP: 1.23950

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 2-amino-4-(methoxymethyl)thiazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Thiazolecarboxylicacid,2-amino-4-(methoxymethyl)-,methylester(9CI)

There total 2 articles about 5-Thiazolecarboxylicacid,2-amino-4-(methoxymethyl)-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

thiourea (17356-08-0) + methyl 2-chloro-4-methoxy-3-oxobutanoate (84746-34-9) → methyl 2-amino-4-(methoxymethyl)thiazole-5-carboxylate (733754-08-0)

Guidance literature:

4-methoxyacetoacetic acid methylester; With sulfuryl dichloride; In dichloromethane; at 20 ℃; for 1h;

thiourea; methyl 2-chloro-4-methoxy-3-oxobutanoate; In ethanol; for 12h;

Reference yield:

4-methoxyacetoacetic acid methylester (41051-15-4) → methyl 2-amino-4-(methoxymethyl)thiazole-5-carboxylate (733754-08-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuryl dichloride / dichloromethane / 20 °C / Inert atmosphere

2: ethanol / 80 °C / Inert atmosphere

With sulfuryl dichloride; In ethanol; dichloromethane;

Reference yield:

methyl 2-amino-4-(methoxymethyl)thiazole-5-carboxylate (733754-08-0) → methyl 2-chloro-4-(methoxymethyl)thiazole-5-carboxylate (907543-81-1)

Guidance literature:

methyl 2-amino-4-(methoxymethyl)thiazole-5-carboxylate; With tert.-butylnitrite; copper(l) chloride; In acetonitrile; at 20 - 70 ℃; for 3h;

With hydrogenchloride; In water;

upstream raw materials:

thiourea

methyl 2-chloro-4-methoxy-3-oxobutanoate

4-methoxyacetoacetic acid methylester

Downstream raw materials:

methyl 2-chloro-4-(methoxymethyl)thiazole-5-carboxylate

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