methyl 2-(1-benzyl-3-((tert-butoxycarbonyl)oxy)-2-oxoindolin-3-yl)acrylate

Base Information

Chemical Name:methyl 2-(1-benzyl-3-((tert-butoxycarbonyl)oxy)-2-oxoindolin-3-yl)acrylate
CAS No.:1360461-96-6
Molecular Formula:C₂₄H₂₅NO₆
Molecular Weight:423.466
Hs Code.:

Synonyms:methyl 2-(1-benzyl-3-((tert-butoxycarbonyl)oxy)-2-oxoindolin-3-yl)acrylate

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Chemical Property of methyl 2-(1-benzyl-3-((tert-butoxycarbonyl)oxy)-2-oxoindolin-3-yl)acrylate

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Technology Process of methyl 2-(1-benzyl-3-((tert-butoxycarbonyl)oxy)-2-oxoindolin-3-yl)acrylate

There total 2 articles about methyl 2-(1-benzyl-3-((tert-butoxycarbonyl)oxy)-2-oxoindolin-3-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(1-benzyl-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)-acrylic acid methyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 1360461-96-6
methyl 2-(1-benzyl-3-((tert-butoxycarbonyl)oxy)-2-oxoindolin-3-yl)acrylate

Guidance literature:: 2-(1-benzyl-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)-acrylic acid methyl ester; With sodium hydride; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

di-tert-butyl dicarbonate; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1002/adsc.201600954

Reference yield:

: 1217-89-6
1-benzylisatin

: 1360461-96-6
methyl 2-(1-benzyl-3-((tert-butoxycarbonyl)oxy)-2-oxoindolin-3-yl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,4-diaza-bicyclo[2.2.2]octane / neat (no solvent) / 20 °C

2.1: sodium hydride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; sodium hydride; In dichloromethane;
DOI:10.1002/adsc.201600954

Reference yield: 95.0%

: 1360461-96-6
methyl 2-(1-benzyl-3-((tert-butoxycarbonyl)oxy)-2-oxoindolin-3-yl)acrylate

: (4-(tert-butyl)phenyl)(3-nitro-1H-indol-1-yl)methanone

: methyl (1S,3aR,8bR)-1'-benzyl-4-(4-(tert-butyl)benzoyl)-8b-nitro-2'-oxo-3a,8b-dihydro-4H-spiro[cyclopenta[b]indole-1,3'-indoline]-2-carboxylate

Guidance literature:: With C₃₇H₄₉N₇O₂S; In 1,2-dichloro-ethane; at 0 ℃; for 50h; stereoselective reaction; Molecular sieve; Inert atmosphere;
DOI:10.1039/d0cc04462h