di-tert-butyl trans-[4-[5-(benzyloxycarbonylamidino)benzofuran-2-carboxamido]cyclohexylamino]diacetate

Base Information

Chemical Name:di-tert-butyl trans-[4-[5-(benzyloxycarbonylamidino)benzofuran-2-carboxamido]cyclohexylamino]diacetate
CAS No.:174774-32-4
Molecular Formula:C₃₆H₄₆N₄O₈
Molecular Weight:662.783
Hs Code.:

Synonyms:di-tert-butyl trans-[4-[5-(benzyloxycarbonylamidino)benzofuran-2-carboxamido]cyclohexylamino]diacetate

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Chemical Property of di-tert-butyl trans-[4-[5-(benzyloxycarbonylamidino)benzofuran-2-carboxamido]cyclohexylamino]diacetate

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Technology Process of di-tert-butyl trans-[4-[5-(benzyloxycarbonylamidino)benzofuran-2-carboxamido]cyclohexylamino]diacetate

There total 9 articles about di-tert-butyl trans-[4-[5-(benzyloxycarbonylamidino)benzofuran-2-carboxamido]cyclohexylamino]diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 174774-65-3
5-(benzyloxycarbonylamidino)-2-benzofurancarboxylic acid

: 174775-01-0
di-tert-butyl trans-(4-aminocyclohexylamino)diacetate

: 174774-32-4
di-tert-butyl trans-[4-[5-(benzyloxycarbonylamidino)benzofuran-2-carboxamido]cyclohexylamino]diacetate

Guidance literature:: With benzotriazol-1-ol; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1248/cpb.47.1694

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 174774-32-4
di-tert-butyl trans-[4-[5-(benzyloxycarbonylamidino)benzofuran-2-carboxamido]cyclohexylamino]diacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 12 percent / K₂CO₃; TEA / dimethylformamide / 4 h / 20 °C

2: 100 percent / H₂ / 10 percent Pd/C / methanol / 7 h / Heating

3: 51 percent / HOBt; EDI / dimethylformamide / 18 h / 20 °C

With TEA; hydrogen; potassium carbonate; benzotriazol-1-ol; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; 1: Alkylation / 2: Hydrogenolysis / 3: coupling;
DOI:10.1248/cpb.47.1694

Reference yield:

: 3114-70-3
trans-1,4-diaminocyclohexane

: 174774-32-4
di-tert-butyl trans-[4-[5-(benzyloxycarbonylamidino)benzofuran-2-carboxamido]cyclohexylamino]diacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 25 percent / TEA / CH₂Cl₂ / 0.75 h / 20 °C

2: 12 percent / K₂CO₃; TEA / dimethylformamide / 4 h / 20 °C

3: 100 percent / H₂ / 10 percent Pd/C / methanol / 7 h / Heating

4: 51 percent / HOBt; EDI / dimethylformamide / 18 h / 20 °C

With TEA; hydrogen; potassium carbonate; benzotriazol-1-ol; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; 1: Alkylation / 2: Alkylation / 3: Hydrogenolysis / 4: coupling;
DOI:10.1248/cpb.47.1694