1-chloro-3-(2-chlorophenyl)isoquinoline

Base Information

• Chemical Name: 1-chloro-3-(2-chlorophenyl)isoquinoline
• CAS No.: 1402452-32-7
• Molecular Formula: C₁₅H₉Cl₂N
• Molecular Weight: 274.149
• Mol file: 1402452-32-7.mol

Synonyms:1-chloro-3-(2-chlorophenyl)isoquinoline

Chemical Property of 1-chloro-3-(2-chlorophenyl)isoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1-chloro-3-(2-chlorophenyl)isoquinoline

There total 3 articles about 1-chloro-3-(2-chlorophenyl)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-phenylisoquinoline 2-oxide (51787-71-4) → 1-chloro-3-(2-chlorophenyl)isoquinoline (1402452-32-7)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); thionyl chloride; tributyl-amine; tetrabutylammonium acetate; zinc(II) oxide; In dimethyl sulfoxide; at 120 ℃; for 36h;

DOI:10.1002/adsc.201101009

Reference yield:

2-phenylethynylbenzaldehyde oxime (106824-49-1) → 1-chloro-3-(2-chlorophenyl)isoquinoline (1402452-32-7)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc(II) chloride / 1,4-dioxane / 12 h / 110 °C

2: dichloro bis(acetonitrile) palladium(II); thionyl chloride; tributyl-amine; tetrabutylammonium acetate; zinc(II) oxide / dimethyl sulfoxide / 36 h / 120 °C

With dichloro bis(acetonitrile) palladium(II); thionyl chloride; tributyl-amine; tetrabutylammonium acetate; zinc(II) oxide; zinc(II) chloride; In 1,4-dioxane; dimethyl sulfoxide;

DOI:10.1002/adsc.201101009

Reference yield:

ortho-bromobenzaldehyde (6630-33-7) → 1-chloro-3-(2-chlorophenyl)isoquinoline (1402452-32-7)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 12 h / 50 °C / Inert atmosphere

2: hydroxylamine hydrochloride / acetonitrile / 10 - 12 h / 20 °C

3: zinc(II) chloride / 1,4-dioxane / 12 h / 110 °C

4: dichloro bis(acetonitrile) palladium(II); thionyl chloride; tributyl-amine; tetrabutylammonium acetate; zinc(II) oxide / dimethyl sulfoxide / 36 h / 120 °C

With bis-triphenylphosphine-palladium(II) chloride; dichloro bis(acetonitrile) palladium(II); copper(l) iodide; thionyl chloride; tributyl-amine; hydroxylamine hydrochloride; tetrabutylammonium acetate; triethylamine; zinc(II) oxide; zinc(II) chloride; In 1,4-dioxane; dimethyl sulfoxide; acetonitrile;

DOI:10.1002/adsc.201101009

upstream raw materials:

3-phenylisoquinoline 2-oxide

2-phenylethynylbenzaldehyde oxime

ortho-bromobenzaldehyde