2-methyl-4aα-(3-methoxyphenyl)-2,3,4,4a,5,6,7,8-octahydro-6α-isoquinolinol acetate

Base Information

Chemical Name:2-methyl-4aα-(3-methoxyphenyl)-2,3,4,4a,5,6,7,8-octahydro-6α-isoquinolinol acetate
CAS No.:118724-82-6
Molecular Formula:C₁₉H₂₅NO₃
Molecular Weight:315.412
Hs Code.:

Synonyms:2-methyl-4aα-(3-methoxyphenyl)-2,3,4,4a,5,6,7,8-octahydro-6α-isoquinolinol acetate

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Chemical Property of 2-methyl-4aα-(3-methoxyphenyl)-2,3,4,4a,5,6,7,8-octahydro-6α-isoquinolinol acetate

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Technology Process of 2-methyl-4aα-(3-methoxyphenyl)-2,3,4,4a,5,6,7,8-octahydro-6α-isoquinolinol acetate

There total 3 articles about 2-methyl-4aα-(3-methoxyphenyl)-2,3,4,4a,5,6,7,8-octahydro-6α-isoquinolinol acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 118724-80-4
Acetic acid (S)-3-bromo-1-[(R)-4-(3-methoxy-phenyl)-1-methyl-1,2,3,4-tetrahydro-pyridin-4-ylmethyl]-propyl ester

: 118724-82-6
2-methyl-4aα-(3-methoxyphenyl)-2,3,4,4a,5,6,7,8-octahydro-6α-isoquinolinol acetate

Guidance literature:: With potassium carbonate; In acetonitrile; for 2h; Yield given; Ambient temperature;
DOI:10.1021/jo00267a039

Reference yield:

: 118724-78-0
(1S^*,3R^*,5S^*)-3-(2-bromoethyl)-5-(3-methoxyphenyl)-8-methyl-2-oxa-8-azabicyclo<3.3.1>nonane

: 118724-82-6
2-methyl-4aα-(3-methoxyphenyl)-2,3,4,4a,5,6,7,8-octahydro-6α-isoquinolinol acetate

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / 1 h / Ambient temperature

2: K₂CO₃ / acetonitrile / 2 h / Ambient temperature

With potassium carbonate; trifluoroacetic acid; In acetonitrile;
DOI:10.1021/jo00267a039

Reference yield:

: 118916-31-7
(1S,3S,5R)-5-(3-Methoxy-phenyl)-8-methyl-3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-2-oxa-8-aza-bicyclo[3.3.1]nonane; hydrochloride

: 118724-82-6
2-methyl-4aα-(3-methoxyphenyl)-2,3,4,4a,5,6,7,8-octahydro-6α-isoquinolinol acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / Ph₃P, Br₂ / tetrahydrofuran / 0.25 h / 10 - 20 °C

2: TFA / 1 h / Ambient temperature

3: K₂CO₃ / acetonitrile / 2 h / Ambient temperature

With bromine; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jo00267a039