2-[(3-amino-propyl)-(3-hydroxy-propyl)-amino]-4-methyl-6-methylsulfanyl-phenol

Base Information

Chemical Name:2-[(3-amino-propyl)-(3-hydroxy-propyl)-amino]-4-methyl-6-methylsulfanyl-phenol
CAS No.:373385-17-2
Molecular Formula:C₁₄H₂₄N₂O₂S
Molecular Weight:284.423
Hs Code.:

Synonyms:2-[(3-amino-propyl)-(3-hydroxy-propyl)-amino]-4-methyl-6-methylsulfanyl-phenol

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Chemical Property of 2-[(3-amino-propyl)-(3-hydroxy-propyl)-amino]-4-methyl-6-methylsulfanyl-phenol

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Technology Process of 2-[(3-amino-propyl)-(3-hydroxy-propyl)-amino]-4-methyl-6-methylsulfanyl-phenol

There total 6 articles about 2-[(3-amino-propyl)-(3-hydroxy-propyl)-amino]-4-methyl-6-methylsulfanyl-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.8%

: 373385-26-3
acetic acid 2-[(2-cyano-ethyl)-(2-methoxymethoxy-5-methyl-3-methylsulfanyl-phenyl)-carbamoyl]-ethyl ester

: 373385-17-2
2-[(3-amino-propyl)-(3-hydroxy-propyl)-amino]-4-methyl-6-methylsulfanyl-phenol

Guidance literature:: With aluminium hydride; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1002/1099-0682(200109)2001:9<2427::AID-EJIC2427>3.0.CO;2-7

Reference yield:

: 20039-91-2
2-bromo-4-methyl-6-nitrophenol

: 373385-17-2
2-[(3-amino-propyl)-(3-hydroxy-propyl)-amino]-4-methyl-6-methylsulfanyl-phenol

Guidance literature:: Multi-step reaction with 6 steps

1.1: aq. NaOH / ethanol / 70 °C

1.2: 86.6 percent / tetrahydrofuran / 4 h / Heating

2.1: phenyllithium / tetrahydrofuran; hexane; diethyl ether / 1 h / -105 °C

2.2: 72.3 percent / tetrahydrofuran; hexane; diethyl ether / 0.5 h / -78 °C

3.1: 90.2 percent / hydrazine / Raney nickel / methanol / 1.5 h / Heating

4.1: 70.9 percent / quinone / Cu(OAc)2*H₂O / 4 h / 110 °C

5.1: 65 percent / triethylamine / diethyl ether; CHCl₃ / 1.5 h / 20 °C

6.1: 84.8 percent / AlH₃ / tetrahydrofuran / 24 h / 20 °C

With aluminium hydride; sodium hydroxide; phenyllithium; triethylamine; p-benzoquinone; hydrazine; copper diacetate; nickel; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; chloroform;
DOI:10.1002/1099-0682(200109)2001:9<2427::AID-EJIC2427>3.0.CO;2-7

Reference yield:

: 155877-01-3
1-Bromo-2-methoxymethoxy-5-methyl-3-nitro-benzene

: 373385-17-2
2-[(3-amino-propyl)-(3-hydroxy-propyl)-amino]-4-methyl-6-methylsulfanyl-phenol

Guidance literature:: Multi-step reaction with 5 steps

1.1: phenyllithium / tetrahydrofuran; hexane; diethyl ether / 1 h / -105 °C

1.2: 72.3 percent / tetrahydrofuran; hexane; diethyl ether / 0.5 h / -78 °C

2.1: 90.2 percent / hydrazine / Raney nickel / methanol / 1.5 h / Heating

3.1: 70.9 percent / quinone / Cu(OAc)2*H₂O / 4 h / 110 °C

4.1: 65 percent / triethylamine / diethyl ether; CHCl₃ / 1.5 h / 20 °C

5.1: 84.8 percent / AlH₃ / tetrahydrofuran / 24 h / 20 °C

With aluminium hydride; phenyllithium; triethylamine; p-benzoquinone; hydrazine; copper diacetate; nickel; In tetrahydrofuran; methanol; diethyl ether; hexane; chloroform;
DOI:10.1002/1099-0682(200109)2001:9<2427::AID-EJIC2427>3.0.CO;2-7