(+)-3-hydroxy-2-(2-(methanesulfonamido)phenylamino)-1-methylmorphinan trifluoroacetate

Base Information

Chemical Name:(+)-3-hydroxy-2-(2-(methanesulfonamido)phenylamino)-1-methylmorphinan trifluoroacetate
CAS No.:1262869-83-9
Molecular Formula:C₂HF₃O₂*C₂₄H₃₁N₃O₃S
Molecular Weight:555.618
Hs Code.:

Synonyms:(+)-3-hydroxy-2-(2-(methanesulfonamido)phenylamino)-1-methylmorphinan trifluoroacetate

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Chemical Property of (+)-3-hydroxy-2-(2-(methanesulfonamido)phenylamino)-1-methylmorphinan trifluoroacetate

Chemical Property:

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Technology Process of (+)-3-hydroxy-2-(2-(methanesulfonamido)phenylamino)-1-methylmorphinan trifluoroacetate

There total 10 articles about (+)-3-hydroxy-2-(2-(methanesulfonamido)phenylamino)-1-methylmorphinan trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1262870-31-4
(+)-3-benzyloxy-2-(2-(methanesulfonamido)phenylamino)-1-methyl-N-(benzyloxycarbonyl)morphinan

: 76-05-1
trifluoroacetic acid

: 1262869-83-9
(+)-3-hydroxy-2-(2-(methanesulfonamido)phenylamino)-1-methylmorphinan trifluoroacetate

Guidance literature:: (+)-3-benzyloxy-2-(2-(methanesulfonamido)phenylamino)-1-methyl-N-(benzyloxycarbonyl)morphinan; With boron tribromide; In dichloromethane; at 0 ℃;

With methanol; In dichloromethane;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 15676-23-0
(+)-3-Hydroxymorphinan

: 1262869-83-9
(+)-3-hydroxy-2-(2-(methanesulfonamido)phenylamino)-1-methylmorphinan trifluoroacetate

Guidance literature:: Multi-step reaction with 10 steps

1: nitric acid; formic acid / water / 0 - 20 °C

2: sodium hydroxide / 1,4-dioxane / 0 - 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 70 °C

4: hydrazine hydrate / Raney nickel / water; methanol / 2 h / 20 °C

5: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 110 °C

6: pyridinium hydrobromide perbromide / tetrahydrofuran / 60 °C

7: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 100 °C

8: hydrazine hydrate / Raney nickel / methanol / 2 h / 20 °C

9: triethylamine / dichloromethane / 0 - 20 °C

10: boron tribromide / dichloromethane / 0 °C

With formic acid; pyridinium hydrobromide perbromide; nitric acid; boron tribromide; potassium carbonate; hydrazine hydrate; triethylamine; sodium hydroxide; sodium t-butanolate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: (+)-3-hydroxymorphinan hydrobromide

: 1262869-83-9
(+)-3-hydroxy-2-(2-(methanesulfonamido)phenylamino)-1-methylmorphinan trifluoroacetate

Guidance literature:: Multi-step reaction with 11 steps

1: sodium hydroxide / 1,4-dioxane; water / 0.5 h / 0 - 20 °C

2: nitric acid; formic acid / water / 0 - 20 °C

3: sodium hydroxide / 1,4-dioxane / 0 - 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 70 °C

5: hydrazine hydrate / Raney nickel / water; methanol / 2 h / 20 °C

6: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 110 °C

7: pyridinium hydrobromide perbromide / tetrahydrofuran / 60 °C

8: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 100 °C

9: hydrazine hydrate / Raney nickel / methanol / 2 h / 20 °C

10: triethylamine / dichloromethane / 0 - 20 °C

11: boron tribromide / dichloromethane / 0 °C

With formic acid; pyridinium hydrobromide perbromide; nitric acid; boron tribromide; potassium carbonate; hydrazine hydrate; triethylamine; sodium hydroxide; sodium t-butanolate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;