(4-benzyl-4-hydroxypiperidin-1-yl)(5-methyl-2-(pyridin-4-yl)-phenyl)methanone

Base Information

Chemical Name:(4-benzyl-4-hydroxypiperidin-1-yl)(5-methyl-2-(pyridin-4-yl)-phenyl)methanone
CAS No.:1429504-60-8
Molecular Formula:C₂₅H₂₆N₂O₂
Molecular Weight:386.494
Hs Code.:

Synonyms:(4-benzyl-4-hydroxypiperidin-1-yl)(5-methyl-2-(pyridin-4-yl)-phenyl)methanone

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Chemical Property of (4-benzyl-4-hydroxypiperidin-1-yl)(5-methyl-2-(pyridin-4-yl)-phenyl)methanone

Chemical Property:

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Technology Process of (4-benzyl-4-hydroxypiperidin-1-yl)(5-methyl-2-(pyridin-4-yl)-phenyl)methanone

There total 4 articles about (4-benzyl-4-hydroxypiperidin-1-yl)(5-methyl-2-(pyridin-4-yl)-phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 51135-96-7
4-benzyl-4-hydroxypiperidine

: 1429505-70-3
5-methyl-2-(pyridin-4-yl)benzoic acid hydrochloride

: 1429504-60-8
(4-benzyl-4-hydroxypiperidin-1-yl)(5-methyl-2-(pyridin-4-yl)-phenyl)methanone

Guidance literature:: With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/acs.jmedchem.1c00864

Reference yield:

: 1429505-69-0
methyl 5-methyl-2-(pyridine-4-yl)benzoate

: 1429504-60-8
(4-benzyl-4-hydroxypiperidin-1-yl)(5-methyl-2-(pyridin-4-yl)-phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; water; acetic acid / 5 h / Reflux

2: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; water; acetic acid; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.1c00864

Reference yield:

: 1692-15-5
4-pyridylboronic acid

: 1429504-60-8
(4-benzyl-4-hydroxypiperidin-1-yl)(5-methyl-2-(pyridin-4-yl)-phenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / Reflux; Inert atmosphere

2: hydrogenchloride; water; acetic acid / 5 h / Reflux

3: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; acetic acid; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.1c00864