(2R,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 4-methyl ester

Base Information

Chemical Name:(2R,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 4-methyl ester
CAS No.:900149-06-6
Molecular Formula:C₃₄H₃₆N₂O₈
Molecular Weight:600.668
Hs Code.:

Synonyms:(2R,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 4-methyl ester

Suppliers and Price of (2R,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 4-methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 4-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 4-methyl ester

There total 3 articles about (2R,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 4-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 900149-05-5
(2R,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester

: 18107-18-1
diazomethyl-trimethyl-silane

: 900149-06-6
(2R,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 4-methyl ester

Guidance literature:: In methanol; diethyl ether;
DOI:10.1021/ol060902q

Reference yield:

: 870097-45-3
(5S,8R)-2,4-dioxo-1,3,7-triaza-spiro[4.4]nonane-7,8-dicarboxylic acid 7-benzyl ester 8-tert-butyl ester

: 900149-06-6
(2R,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 4-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: Boc₂O; DMAP / tetrahydrofuran / 4 h / cooling

1.2: 73 percent / KOH / tetrahydrofuran; H₂O / 20 °C

2.1: TMS-Cl; diisopropylethylamine / CH₂Cl₂ / 2 h / Heating

2.2: 78 percent / CH₂Cl₂ / 0 - 20 °C

3.1: 90 percent / diethyl ether; methanol

With dmap; chloro-trimethyl-silane; di-tert-butyl dicarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/ol060902q

Reference yield:

: 900149-04-4
(3S,5R)-3-amino-1-((benzyloxy)carbonyl)-5-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid

: 900149-06-6
(2R,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 4-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: TMS-Cl; diisopropylethylamine / CH₂Cl₂ / 2 h / Heating

1.2: 78 percent / CH₂Cl₂ / 0 - 20 °C

2.1: 90 percent / diethyl ether; methanol

With chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/ol060902q