(3S)-1-(3-benzyl-5-tert-butyl-triazolo[4,5-d]pyrimidin-7-yl)pyrrolidin-3-ol

Base Information

Chemical Name:(3S)-1-(3-benzyl-5-tert-butyl-triazolo[4,5-d]pyrimidin-7-yl)pyrrolidin-3-ol
CAS No.:1433362-34-5
Molecular Formula:C₁₉H₂₄N₆O
Molecular Weight:352.439
Hs Code.:

Synonyms:(3S)-1-(3-benzyl-5-tert-butyl-triazolo[4,5-d]pyrimidin-7-yl)pyrrolidin-3-ol

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Chemical Property of (3S)-1-(3-benzyl-5-tert-butyl-triazolo[4,5-d]pyrimidin-7-yl)pyrrolidin-3-ol

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Technology Process of (3S)-1-(3-benzyl-5-tert-butyl-triazolo[4,5-d]pyrimidin-7-yl)pyrrolidin-3-ol

There total 7 articles about (3S)-1-(3-benzyl-5-tert-butyl-triazolo[4,5-d]pyrimidin-7-yl)pyrrolidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433363-46-2
3-benzyl-5-tert-butyl-7-chloro-triazolo[4,5-d]pyrimidine

: 100243-39-8
3-hydroxypyrrolidine

: 1433362-34-5
(3S)-1-(3-benzyl-5-tert-butyl-triazolo[4,5-d]pyrimidin-7-yl)pyrrolidin-3-ol

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 - 30 ℃; for 2.5h;

Reference yield:

: 4342-08-9
4-amino-3-benzyl-1,2,3-triazole-5-carboxamide

: 1433362-34-5
(3S)-1-(3-benzyl-5-tert-butyl-triazolo[4,5-d]pyrimidin-7-yl)pyrrolidin-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / N,N-dimethyl acetamide / 1.5 h / 80 °C

1.2: 2 h / 80 °C / Inert atmosphere

2.1: potassium hydrogencarbonate / N,N-dimethyl acetamide / 18.5 h / 1555 °C

2.2: 2 h / 80 °C / Inert atmosphere

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 35 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 20 - 30 °C

With pyridine; oxalyl dichloride; potassium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl acetamide; acetonitrile;

Reference yield:

: 100-44-7
benzyl chloride

: 1433362-34-5
(3S)-1-(3-benzyl-5-tert-butyl-triazolo[4,5-d]pyrimidin-7-yl)pyrrolidin-3-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium azide; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 4 h / 25 °C

2.1: sodium hydroxide / water; dimethyl sulfoxide / 4.25 h / 25 °C

3.1: pyridine / N,N-dimethyl acetamide / 1.5 h / 80 °C

3.2: 2 h / 80 °C / Inert atmosphere

4.1: potassium hydrogencarbonate / N,N-dimethyl acetamide / 18.5 h / 1555 °C

4.2: 2 h / 80 °C / Inert atmosphere

5.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 35 °C

6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 20 - 30 °C

With pyridine; sodium azide; oxalyl dichloride; potassium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; acetonitrile;