methyl 1-(3-amino-6-(3-methoxyphenyl)pyrazin-2-yl)piperidine-4-carboxylate

Base Information

• Chemical Name: methyl 1-(3-amino-6-(3-methoxyphenyl)pyrazin-2-yl)piperidine-4-carboxylate
• CAS No.: 1254328-42-1
• Molecular Formula: C₁₈H₂₂N₄O₃
• Molecular Weight: 342.398
• Mol file: 1254328-42-1.mol

Synonyms:methyl 1-(3-amino-6-(3-methoxyphenyl)pyrazin-2-yl)piperidine-4-carboxylate

Chemical Property of methyl 1-(3-amino-6-(3-methoxyphenyl)pyrazin-2-yl)piperidine-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 1-(3-amino-6-(3-methoxyphenyl)pyrazin-2-yl)piperidine-4-carboxylate

There total 1 articles about methyl 1-(3-amino-6-(3-methoxyphenyl)pyrazin-2-yl)piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

methyl 1-(3-amino-6-bromopyrazin-2-yl)piperidine-4-carboxylate + 3-methoxyphenylboronic acid (10365-98-7,1107579-37-2) → methyl 1-(3-amino-6-(3-methoxyphenyl)pyrazin-2-yl)piperidine-4-carboxylate (1254328-42-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 100 ℃; for 1h; Microwave irradiation;

DOI:10.1021/jm1008727

Reference yield: 100.0%

methyl 1-(3-amino-6-(3-methoxyphenyl)pyrazin-2-yl)piperidine-4-carboxylate (1254328-42-1) → 1-(3-amino-6-(3-methoxyphenyl)pyrazin-2-yl)piperidine-4-carboxylic acid (1254327-58-6)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 18h;

DOI:10.1021/jm1008727

upstream raw materials:

3-methoxyphenylboronic acid

Downstream raw materials:

1-(3-amino-6-(3-methoxyphenyl)pyrazin-2-yl)piperidine-4-carboxylic acid