N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine 2'-<2-(4-Nitrophenyl)ethyl N,N-Octamethylenephosphoramidite>

Base Information

• Chemical Name: N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine 2'-<2-(4-Nitrophenyl)ethyl N,N-Octamethylenephosphoramidite>
• CAS No.: 121409-41-4
• Molecular Formula: C₅₉H₇₀N₇O₉PSi
• Molecular Weight: 1080.31
• Mol file: 121409-41-4.mol

Synonyms:N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine 2'-<2-(4-Nitrophenyl)ethyl N,N-Octamethylenephosphoramidite>

Chemical Property of N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine 2'-<2-(4-Nitrophenyl)ethyl N,N-Octamethylenephosphoramidite>

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine 2'-<2-(4-Nitrophenyl)ethyl N,N-Octamethylenephosphoramidite>

There total 1 articles about N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine 2'-<2-(4-Nitrophenyl)ethyl N,N-Octamethylenephosphoramidite> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N6-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine (69504-10-5) + chloro<2-(4-nitrophenyl)ethoxy>(octahydro-1H-azonin-1-yl)phosphane (95645-44-6) → N6-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine 2'-<2-(4-Nitrophenyl)ethyl N,N-Octamethylenephosphoramidite> (121409-41-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1002/hlca.19920750206

Reference yield:

N6-benzoyl-2',3'-bis-O-<(1,1-dimethylethyl)dimethylsilyl>adenosine (79974-68-8) + N6-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine 2'-<2-(4-Nitrophenyl)ethyl N,N-Octamethylenephosphoramidite> (121409-41-4) → (PS)-N6-benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-P-thioadenylyl<2'-P-<2-(4-nitrophenyl)ethyl>>->5'>-N6-benzoyl-2',3'-bis-O-<(tert-butyl)dimethylsilyl>adenosine (111005-86-8,111137-52-1) + (PR)-N6-benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-P-thioadenylyl<2'-P-<2-(4-nitrophenyl)ethyl>>->5'>-N6-benzoyl-2',3'-bis-O-<(tert-butyl)dimethylsilyl>adenosine (111005-86-8,111137-52-1)

Guidance literature:

With pyridine; sulfur; 3-nitro-1,2,4-triazole; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₃CN, r.t., 3 h, 2.) r.t., 20 h;

DOI:10.1002/hlca.19920750206

Reference yield:

N6-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine 2'-<2-(4-Nitrophenyl)ethyl N,N-Octamethylenephosphoramidite> (121409-41-4) + (PS)-N6-benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-P-thioadenylyl<2'-P-<2-(4-nitrophenyl)ethyl>>->5'>-N6-benzoyl-2',3'-bis-O-<(tert-butyl)dimethylsilyl>adenosine (111005-87-9) → C111H135N17O22P2S2Si4 (111005-88-0,111058-59-4,111058-60-7,111058-61-8) + C111H135N17O22P2S2Si4 (111005-88-0,111058-59-4,111058-60-7,111058-61-8)

Guidance literature:

With pyridine; sulfur; 3-nitro-1,2,4-triazole; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₃CN, r.t., 3 h, 2.) r.t., 20 h;

DOI:10.1002/hlca.19920750206

upstream raw materials:

N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine

chloro<2-(4-nitrophenyl)ethoxy>(octahydro-1H-azonin-1-yl)phosphane

Downstream raw materials:

(PS)-N⁶-benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-P-thioadenylyl<2'-P-<2-(4-nitrophenyl)ethyl>>->5'>-N⁶-benzoyl-2',3'-bis-O-<(tert-butyl)dimethylsilyl>adenosine

(PR)-N⁶-benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-P-thioadenylyl<2'-P-<2-(4-nitrophenyl)ethyl>>->5'>-N⁶-benzoyl-2',3'-bis-O-<(tert-butyl)dimethylsilyl>adenosine

C₁₁₁H₁₃₅N₁₇O₂₂P₂S₂Si₄

C₁₁₁H₁₃₅N₁₇O₂₂P₂S₂Si₄