(E)-3-(6-((E)-3-(pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine-2-yl)acrylaldehyde

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Chemical Name:(E)-3-(6-((E)-3-(pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine-2-yl)acrylaldehyde
CAS No.:188183-20-2
Molecular Formula:C₂₂H₂₄N₂O
Molecular Weight:332.445
Hs Code.:

Synonyms:(E)-3-(6-((E)-3-(pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine-2-yl)acrylaldehyde

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Chemical Property of (E)-3-(6-((E)-3-(pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine-2-yl)acrylaldehyde

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Technology Process of (E)-3-(6-((E)-3-(pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine-2-yl)acrylaldehyde

There total 4 articles about (E)-3-(6-((E)-3-(pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine-2-yl)acrylaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 178417-05-5
(E)-3-(6-[3-pyrrolidino-1-{4-tolyl}-prop-1E-enyl]-pyridin-2-yl)-prop-2-en-1-ol

: N-Methyl-4-(1H-2-methylimidazo[4,5-c]pyridin-1-ylmethyl)-N-{3-[6-(3-pyrrolidin-1-yl-1-{4-tolyl}-prop-1E-enyl)-pyridin-2-yl]-prop-2E-enyl}-benzamide

: 188183-20-2
(E)-3-(6-((E)-3-(pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine-2-yl)acrylaldehyde

Guidance literature:: With manganese dioxide; In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

Reference yield: 59.0%

: 178417-05-5
(E)-3-(6-[3-pyrrolidino-1-{4-tolyl}-prop-1E-enyl]-pyridin-2-yl)-prop-2-en-1-ol

: 188183-20-2
(E)-3-(6-((E)-3-(pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine-2-yl)acrylaldehyde

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1021/acs.joc.0c01877

Reference yield:

: acrivastine

: 188183-20-2
(E)-3-(6-((E)-3-(pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine-2-yl)acrylaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: chloro-trimethyl-silane / 50 °C / Inert atmosphere

2: diisobutylaluminium hydride / dichloromethane; hexane / -10 °C / Inert atmosphere

3: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C

With chloro-trimethyl-silane; diisobutylaluminium hydride; Dess-Martin periodane; In hexane; dichloromethane;
DOI:10.1021/acs.joc.0c01877