1-(4-(4-(4-(2-aminophenoxy)-5-chloropyrimidin-2-ylamino)-3-methoxy phenyl)piperazin-1-yl)ethanone

Base Information

Chemical Name:1-(4-(4-(4-(2-aminophenoxy)-5-chloropyrimidin-2-ylamino)-3-methoxy phenyl)piperazin-1-yl)ethanone
CAS No.:1622003-32-0
Molecular Formula:C₂₃H₂₅ClN₆O₃
Molecular Weight:468.943
Hs Code.:

Synonyms:1-(4-(4-(4-(2-aminophenoxy)-5-chloropyrimidin-2-ylamino)-3-methoxy phenyl)piperazin-1-yl)ethanone

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Chemical Property of 1-(4-(4-(4-(2-aminophenoxy)-5-chloropyrimidin-2-ylamino)-3-methoxy phenyl)piperazin-1-yl)ethanone

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Technology Process of 1-(4-(4-(4-(2-aminophenoxy)-5-chloropyrimidin-2-ylamino)-3-methoxy phenyl)piperazin-1-yl)ethanone

There total 3 articles about 1-(4-(4-(4-(2-aminophenoxy)-5-chloropyrimidin-2-ylamino)-3-methoxy phenyl)piperazin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.7%

: 1622003-31-9
1-(4-(4-(5-chloro-4-(2-nitrophenoxy)pyrimidin-2-ylamino)-3-methoxyphenyl)piperazin-1-yl)ethanone

: 1622003-32-0
1-(4-(4-(4-(2-aminophenoxy)-5-chloropyrimidin-2-ylamino)-3-methoxy phenyl)piperazin-1-yl)ethanone

Guidance literature:: With ammonium chloride; zinc; In 1,4-dioxane; water; at 20 ℃; for 0.5h;

Reference yield:

: 88-75-5,78813-12-4
2-hydroxynitrobenzene

: 1622003-32-0
1-(4-(4-(4-(2-aminophenoxy)-5-chloropyrimidin-2-ylamino)-3-methoxy phenyl)piperazin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / 100 °C

2: toluene-4-sulfonic acid / 1,4-dioxane / 16 h / 100 °C

3: zinc; ammonium chloride / 1,4-dioxane; water / 0.5 h / 20 °C

With ammonium chloride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; zinc; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water;

Reference yield:

: 1035562-29-8
2,5-dichloro-4-(2-nitrophenoxy)pyrimidine

: 1622003-32-0
1-(4-(4-(4-(2-aminophenoxy)-5-chloropyrimidin-2-ylamino)-3-methoxy phenyl)piperazin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 1,4-dioxane / 16 h / 100 °C

2: zinc; ammonium chloride / 1,4-dioxane; water / 0.5 h / 20 °C

With ammonium chloride; toluene-4-sulfonic acid; zinc; In 1,4-dioxane; water;