1-[6-{[tert-butyl(diphenyl)silyl]oxy}-9-(cyclopropylmethoxy)benzo[h]quinolin-2-yl]-2-methylpropan-2-ol

Base Information

Chemical Name:1-[6-{[tert-butyl(diphenyl)silyl]oxy}-9-(cyclopropylmethoxy)benzo[h]quinolin-2-yl]-2-methylpropan-2-ol
CAS No.:958219-74-4
Molecular Formula:C₃₇H₄₁NO₃Si
Molecular Weight:575.823
Hs Code.:

Synonyms:1-[6-{[tert-butyl(diphenyl)silyl]oxy}-9-(cyclopropylmethoxy)benzo[h]quinolin-2-yl]-2-methylpropan-2-ol

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Chemical Property of 1-[6-{[tert-butyl(diphenyl)silyl]oxy}-9-(cyclopropylmethoxy)benzo[h]quinolin-2-yl]-2-methylpropan-2-ol

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Technology Process of 1-[6-{[tert-butyl(diphenyl)silyl]oxy}-9-(cyclopropylmethoxy)benzo[h]quinolin-2-yl]-2-methylpropan-2-ol

There total 10 articles about 1-[6-{[tert-butyl(diphenyl)silyl]oxy}-9-(cyclopropylmethoxy)benzo[h]quinolin-2-yl]-2-methylpropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 958219-73-3
1-[6-{tert-butyl(diphenyl)silyl}oxy-9-(cyclopropylmethoxy)benzo[h]quinolin-2-yl]acetone

: 958219-74-4
1-[6-{[tert-butyl(diphenyl)silyl]oxy}-9-(cyclopropylmethoxy)benzo[h]quinolin-2-yl]-2-methylpropan-2-ol

Guidance literature:: methyllithium; With titanium tetrachloride; In diethyl ether; dichloromethane; at -78 ℃; for 0.5h;

1-[6-{tert-butyl(diphenyl)silyl}oxy-9-(cyclopropylmethoxy)benzo[h]quinolin-2-yl]acetone; In diethyl ether; dichloromethane; at -78 - 0 ℃; for 5h;

With hydrogenchloride; water; In diethyl ether; dichloromethane; ethyl acetate; Product distribution / selectivity;

Reference yield:

: 958219-61-9
2-chloro-9-methoxybenzo[h]quinolin-6-ol

: 958219-74-4
1-[6-{[tert-butyl(diphenyl)silyl]oxy}-9-(cyclopropylmethoxy)benzo[h]quinolin-2-yl]-2-methylpropan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 36 h / 20 °C

2.1: boron tribromide; triethylamine / 1,1-dichloroethane / 5.67 h / -10 - 20 °C

3.1: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / 20 °C

4.1: tributyltin methoxide / palladium diacetate; tris-(o-tolyl)phosphine / toluene / 3 h / 100 - 120 °C

5.1: titanium tetrachloride / diethyl ether; dichloromethane / 0.5 h / -78 °C

5.2: 5 h / -78 - 0 °C

With 1H-imidazole; di-tert-butyl-diazodicarboxylate; tributyltin methoxide; boron tribromide; titanium tetrachloride; triethylamine; triphenylphosphine; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; diethyl ether; 1,1-dichloroethane; dichloromethane; N,N-dimethyl-formamide; toluene; 3.1: Mitsunobu reaction;

Reference yield:

: 958219-65-3
methyl [6-chloro-2-(3-methoxyphenyl)pyridine-3-yl]acetate

: 958219-74-4
1-[6-{[tert-butyl(diphenyl)silyl]oxy}-9-(cyclopropylmethoxy)benzo[h]quinolin-2-yl]-2-methylpropan-2-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: methanol; sodium hydroxide; water / tetrahydrofuran / 0.33 h / 0 - 20 °C

2.1: triethylamine / tetrahydrofuran / 19 h / Heating / reflux

3.1: aluminum (III) chloride / dichloromethane / 0.5 h / 70 °C

4.1: 1H-imidazole / N,N-dimethyl-formamide / 36 h / 20 °C

5.1: boron tribromide; triethylamine / 1,1-dichloroethane / 5.67 h / -10 - 20 °C

6.1: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / 20 °C

7.1: tributyltin methoxide / palladium diacetate; tris-(o-tolyl)phosphine / toluene / 3 h / 100 - 120 °C

8.1: titanium tetrachloride / diethyl ether; dichloromethane / 0.5 h / -78 °C

8.2: 5 h / -78 - 0 °C

With 1H-imidazole; methanol; sodium hydroxide; di-tert-butyl-diazodicarboxylate; water; tributyltin methoxide; boron tribromide; titanium tetrachloride; triethylamine; triphenylphosphine; aluminum (III) chloride; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; diethyl ether; 1,1-dichloroethane; dichloromethane; N,N-dimethyl-formamide; toluene; 6.1: Mitsunobu reaction;