(3-(4-chlorophenyl)-6-methyl-6,11-dihydro-5H-indolizino[6,7-b]indole-1,2-diyl)dimethanol

Base Information

Chemical Name:(3-(4-chlorophenyl)-6-methyl-6,11-dihydro-5H-indolizino[6,7-b]indole-1,2-diyl)dimethanol
CAS No.:1422377-07-8
Molecular Formula:C₂₃H₂₁ClN₂O₂
Molecular Weight:392.885
Hs Code.:

Synonyms:(3-(4-chlorophenyl)-6-methyl-6,11-dihydro-5H-indolizino[6,7-b]indole-1,2-diyl)dimethanol

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Chemical Property of (3-(4-chlorophenyl)-6-methyl-6,11-dihydro-5H-indolizino[6,7-b]indole-1,2-diyl)dimethanol

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Technology Process of (3-(4-chlorophenyl)-6-methyl-6,11-dihydro-5H-indolizino[6,7-b]indole-1,2-diyl)dimethanol

There total 9 articles about (3-(4-chlorophenyl)-6-methyl-6,11-dihydro-5H-indolizino[6,7-b]indole-1,2-diyl)dimethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1422376-98-4
dimethyl 3-(4-chlorophenyl)-6-methyl-6,11-dihydro-5H-indolizino-[6,7-b]indole-1,2-dicarboxylate

: 1422377-07-8
(3-(4-chlorophenyl)-6-methyl-6,11-dihydro-5H-indolizino[6,7-b]indole-1,2-diyl)dimethanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; dichloromethane; at -5 - 0 ℃; for 0.5h;
DOI:10.1021/jm301788a

Reference yield:

: 7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8
(S)-tryptophan methyl ester hydrochloride

: 1422377-07-8
(3-(4-chlorophenyl)-6-methyl-6,11-dihydro-5H-indolizino[6,7-b]indole-1,2-diyl)dimethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; methanol / 5 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 9 h / Reflux

3.1: sodium hydride / mineral oil; tetrahydrofuran / 0.25 h / 0 - 5 °C

3.2: 9 h / 0 - 20 °C

3.3: pH 6

4.1: acetic anhydride / 60 - 75 °C

5.1: lithium aluminium tetrahydride / diethyl ether; dichloromethane / 0.5 h / -5 - 0 °C

With lithium aluminium tetrahydride; acetic anhydride; sodium hydride; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; mineral oil; 1.1: |Pictet-Spengler Synthesis;
DOI:10.1021/jm301788a

Reference yield:

: 79815-18-2
methyl (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylate

: 1422377-07-8
(3-(4-chlorophenyl)-6-methyl-6,11-dihydro-5H-indolizino[6,7-b]indole-1,2-diyl)dimethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 9 h / Reflux

2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.25 h / 0 - 5 °C

2.2: 9 h / 0 - 20 °C

2.3: pH 6

3.1: acetic anhydride / 60 - 75 °C

4.1: lithium aluminium tetrahydride / diethyl ether; dichloromethane / 0.5 h / -5 - 0 °C

With lithium aluminium tetrahydride; acetic anhydride; sodium hydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; mineral oil;
DOI:10.1021/jm301788a