(S)-2-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid ethyl ester

Base Information

Chemical Name:(S)-2-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid ethyl ester
CAS No.:1064684-30-5
Molecular Formula:C₂₁H₂₇FN₃O₉P
Molecular Weight:515.432
Hs Code.:

(S)-2-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid ethyl ester

Synonyms:(S)-2-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid ethyl ester

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Chemical Property of (S)-2-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid ethyl ester

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Technology Process of (S)-2-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid ethyl ester

There total 7 articles about (S)-2-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1315584-52-1
C₂₉H₃₃FN₃O₁₁P

: 1064684-30-5,2164516-85-0
(S)-2-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid ethyl ester

Guidance literature:: With cyclohexa-1,4-diene; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 3h;
DOI:10.1016/j.tet.2011.05.046

Reference yield:

: 863329-66-2,2041584-99-8
2'-deoxy-2'-fluoro-2'-methyluridine

: 245078-14-2
(2S)-ethyl 2-(chloro(phenoxy)phosphorylamino)propanoate

: 1064684-30-5,2164516-85-0
(S)-2-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid ethyl ester

: C₂₁H₂₇FN₃O₉P

: C₃₂H₄₁FN₄O₁₃P₂

Guidance literature:: With 1-methyl-1H-imidazole; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm100863x

Reference yield:

: 863329-66-2,2041584-99-8
2'-deoxy-2'-fluoro-2'-methyluridine

: 1064684-30-5,2164516-85-0
(S)-2-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine; 1H-imidazole / 0 - 20 °C / Inert atmosphere

2: dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

3: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: 1-methyl-1H-imidazole / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

5: palladium 10% on activated carbon; cyclohexa-1,4-diene / ethanol / 3 h / 20 °C

With pyridine; 1H-imidazole; 1-methyl-1H-imidazole; dmap; cyclohexa-1,4-diene; palladium 10% on activated carbon; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.tet.2011.05.046