2-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carboxamide

Base Information

Chemical Name:2-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carboxamide
CAS No.:1402652-17-8
Molecular Formula:C₁₉H₁₉N₃O₃
Molecular Weight:337.378
Hs Code.:

Synonyms:2-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carboxamide

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Chemical Property of 2-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carboxamide

Chemical Property:

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Technology Process of 2-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carboxamide

There total 10 articles about 2-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402652-14-5
2-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carbonitrile

: 1402652-17-8
2-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carboxamide

: 1402652-16-7
2-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carboximidamide

Guidance literature:: With water; hydroxylamine; In methanol; at 0 - 1 ℃; for 23h; Inert atmosphere;

Reference yield:

: 1402652-32-7
4-(3-bromo-1,4,5,6-tetrahydrocyclopenta[b]pyrrol-2-yl)-3,5-dimethylisoxazole

: 1402652-17-8
2-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carboxamide

: 1402652-16-7
2-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carboximidamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap; triethylamine / acetonitrile / 1.5 h / Inert atmosphere

2.1: potassium carbonate; sodium iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1.5 h / 90 °C / Inert atmosphere

3.1: sodium methylate; methanol / tetrahydrofuran / 16 h / 45 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

4.2: 0 °C

5.1: boron dimethyl-trifluoro sulphide / dichloromethane / 64 h / 2 °C / Inert atmosphere

5.2: 0 °C

6.1: water; hydroxylamine / methanol / 23 h / 0 - 1 °C / Inert atmosphere

With methanol; dmap; boron dimethyl-trifluoro sulphide; water; hydroxylamine; sodium methylate; sodium hydride; potassium carbonate; triethylamine; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile;

Reference yield:

: 1402652-33-8
tert-butyl 3-bromo-2-(3,5-dimethylisoxazol-4-yl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carboxylate

: 1402652-17-8
2-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carboxamide

: 1402652-16-7
2-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carboximidamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; sodium iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1.5 h / 90 °C / Inert atmosphere

2.1: sodium methylate; methanol / tetrahydrofuran / 16 h / 45 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

3.2: 0 °C

4.1: boron dimethyl-trifluoro sulphide / dichloromethane / 64 h / 2 °C / Inert atmosphere

4.2: 0 °C

5.1: water; hydroxylamine / methanol / 23 h / 0 - 1 °C / Inert atmosphere

With methanol; boron dimethyl-trifluoro sulphide; water; hydroxylamine; sodium methylate; sodium hydride; potassium carbonate; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water;