(2R,4S)-4-Fluoro-D-proline methyl ester

Base Information

Chemical Name:(2R,4S)-4-Fluoro-D-proline methyl ester
CAS No.:732957-04-9
Molecular Formula:C₆H₁₀FNO₂
Molecular Weight:147.149
Hs Code.:
DSSTox Substance ID:DTXSID20554772
Wikidata:Q82435937
Mol file:732957-04-9.mol

Synonyms:732957-04-9;(2R,4S)-4-FLUORO-D-PROLINE METHYL ESTER;METHYL (2R,4S)-4-FLUOROPYRROLIDINE-2-CARBOXYLATE;D-Proline, 4-fluoro-,methyl ester, (4S)-;SCHEMBL13403388;DTXSID20554772;Methyl (4S)-4-fluoro-D-prolinate;EN300-1068717

Suppliers and Price of (2R,4S)-4-Fluoro-D-proline methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(2R,4S)-4-FLUORO-D-PROLINE METHYL ESTER 95.00%
5MG
$ 500.23

Total 2 raw suppliers

Chemical Property of (2R,4S)-4-Fluoro-D-proline methyl ester

Chemical Property:

PSA：38.33000
LogP:0.18820
XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:147.06955672
Heavy Atom Count:10
Complexity:140

Purity/Quality:: (2R,4S)-4-FLUORO-D-PROLINE METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1CC(CN1)F
Isomeric SMILES:COC(=O)[C@H]1C[C@@H](CN1)F

Technology Process of (2R,4S)-4-Fluoro-D-proline methyl ester

There total 4 articles about (2R,4S)-4-Fluoro-D-proline methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 203866-16-4
1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate

: 1313017-51-4,475561-83-2,732957-04-9
(2S,4S)-methyl 4-fluoropyrrolidine-2-carboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1039/c8cc05588b

Reference yield: 70.0%

: (2S,4S)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride

: 191793-72-3,475561-83-2,732957-04-9
(S)-4-Fluoro-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: With 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane; at -15 ℃; for 0.75h;
DOI:10.1016/S0022-1139(96)03568-3

Reference yield: 61.0%

: 203866-18-6
methyl (2S,4R)-N-(tert-butyloxy)carbonyl-4-fluoropyrrolidine-2-carboxylate

: 1313017-51-4,475561-83-2,732957-04-9
methyl (2S,4R)-4-fluoropyrrolidine-2-carboxylate

Guidance literature:: methyl (2S,4R)-N-(tert-butyloxy)carbonyl-4-fluoropyrrolidine-2-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

With potassium carbonate; In dichloromethane; for 1h; Inert atmosphere;
DOI:10.1021/acs.orglett.7b01748