4-(4-methoxyphenyl-1-yl)-3-hydroxy-1-(4-methoxyphenyl)-1-butanone

Base Information

• Chemical Name: 4-(4-methoxyphenyl-1-yl)-3-hydroxy-1-(4-methoxyphenyl)-1-butanone
• CAS No.: 1158956-44-5
• Molecular Formula: C₁₈H₂₀O₄
• Molecular Weight: 300.354
• Mol file: 1158956-44-5.mol

Synonyms:4-(4-methoxyphenyl-1-yl)-3-hydroxy-1-(4-methoxyphenyl)-1-butanone

Chemical Property of 4-(4-methoxyphenyl-1-yl)-3-hydroxy-1-(4-methoxyphenyl)-1-butanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-methoxyphenyl-1-yl)-3-hydroxy-1-(4-methoxyphenyl)-1-butanone

There total 3 articles about 4-(4-methoxyphenyl-1-yl)-3-hydroxy-1-(4-methoxyphenyl)-1-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

3-(4-methoxyphenyl)-5-(4-methoxybenzyl)-4,5-dihydroisoxazole (1158556-84-3) → 4-(4-methoxyphenyl-1-yl)-3-hydroxy-1-(4-methoxyphenyl)-1-butanone (1158956-44-5)

Guidance literature:

With hydrogen; boric acid; In methanol; water; at 20 ℃; for 48h; under 760.051 Torr;

DOI:10.1021/acs.jnatprod.5b01007

Reference yield: 61.0%

→ 4-(4-methoxyphenyl-1-yl)-3-hydroxy-1-(4-methoxyphenyl)-1-butanone (1158956-44-5)

Guidance literature:

Reference yield:

Estragole (140-67-0) + N-hydroxy-4-methoxy-benzenecarboximidoyl chloride (38435-51-7) → 4-(4-methoxyphenyl-1-yl)-3-hydroxy-1-(4-methoxyphenyl)-1-butanone (1158956-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 17 h / 0 - 20 °C

2: boric acid; hydrogen / methanol; water / 48 h / 20 °C / 760.05 Torr

With hydrogen; boric acid; triethylamine; In methanol; dichloromethane; water;

DOI:10.1021/acs.jnatprod.5b01007

upstream raw materials:

3-(4-methoxyphenyl)-5-(4-methoxybenzyl)-4,5-dihydroisoxazole

Estragole

N-hydroxy-4-methoxy-benzenecarboximidoyl chloride