N^α-[3-(tert-butyloxycarbonylamino)-2(R,S)-azidopropionyl]-leucyl-O-methyl-tyrosine N-methylamide

Base Information

• Chemical Name: N^α-[3-(tert-butyloxycarbonylamino)-2(R,S)-azidopropionyl]-leucyl-O-methyl-tyrosine N-methylamide
• CAS No.: 458532-00-8
• Molecular Formula: C₂₅H₃₉N₇O₆
• Molecular Weight: 533.628

Synonyms:N^α-[3-(tert-butyloxycarbonylamino)-2(R,S)-azidopropionyl]-leucyl-O-methyl-tyrosine N-methylamide

Chemical Property of N^α-[3-(tert-butyloxycarbonylamino)-2(R,S)-azidopropionyl]-leucyl-O-methyl-tyrosine N-methylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-[3-(tert-butyloxycarbonylamino)-2(R,S)-azidopropionyl]-leucyl-O-methyl-tyrosine N-methylamide

There total 5 articles about N^α-[3-(tert-butyloxycarbonylamino)-2(R,S)-azidopropionyl]-leucyl-O-methyl-tyrosine N-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Methanesulfonic acid 2-tert-butoxycarbonylamino-1-{(S)-1-[(S)-2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-3-methyl-butylcarbamoyl}-ethyl ester → Nα-[3-(tert-butyloxycarbonylamino)-2(R,S)-azidopropionyl]-leucyl-O-methyl-tyrosine N-methylamide (458532-00-8)

Guidance literature:

With sodium azide; at 20 ℃; for 20h;

DOI:10.1248/cpb.50.239

Reference yield:

3-tert-butyloxycarbonylamino-2(RS)-hydroxypropionic acid (218916-64-4) → Nα-[3-(tert-butyloxycarbonylamino)-2(R,S)-azidopropionyl]-leucyl-O-methyl-tyrosine N-methylamide (458532-00-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / EDC; Et₃N; HOBt / dimethylformamide / 21 h / -3 - 0 °C

2: pyridine / CH₂Cl₂ / 2 h / 0 °C

3: 88 percent / sodium azide / 20 h / 20 °C

With pyridine; sodium azide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.50.239

Reference yield:

Boc-Leu-Tyr(Me)-NHMe → Nα-[3-(tert-butyloxycarbonylamino)-2(R,S)-azidopropionyl]-leucyl-O-methyl-tyrosine N-methylamide (458532-00-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 4 N HCl / ethyl acetate

2: 70 percent / EDC; Et₃N; HOBt / dimethylformamide / 21 h / -3 - 0 °C

3: pyridine / CH₂Cl₂ / 2 h / 0 °C

4: 88 percent / sodium azide / 20 h / 20 °C

With pyridine; hydrogenchloride; sodium azide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1248/cpb.50.239

upstream raw materials:

3-tert-butyloxycarbonylamino-2(RS)-hydroxypropionic acid

(2-Hydroxy-2-{(S)-1-[(S)-2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-3-methyl-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 458532-00-8 N^α-[3-(tert-butyloxycarbonylamino)-2(R,S)-azidopropionyl]-leucyl-O-methyl-tyrosine N-methylamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send