18-methyl-estra-4-en-3,11,17-trione

Base Information

Chemical Name:18-methyl-estra-4-en-3,11,17-trione
CAS No.:100071-90-7
Molecular Formula:C₁₉H₂₄O₃
Molecular Weight:300.398
Hs Code.:

Synonyms:18-methyl-estra-4-en-3,11,17-trione

Suppliers and Price of 18-methyl-estra-4-en-3,11,17-trione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of 18-methyl-estra-4-en-3,11,17-trione

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 18-methyl-estra-4-en-3,11,17-trione

There total 1 articles about 18-methyl-estra-4-en-3,11,17-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 53067-82-6,170901-07-2
13β-ethyl-11α-hydroxygon-5-ene-3,17-dione

: 100071-90-7
18-methyl-estra-4-en-3,11,17-trione

Guidance literature:: With jones' reagent; In acetone; at -15 - -10 ℃; for 0.25h;
DOI:10.1080/00304949709355234

Reference yield:

: 100071-90-7
18-methyl-estra-4-en-3,11,17-trione

: 54024-21-4
11-methylene-18a-homo-estr-4-en-17-one

Guidance literature:: Multi-step reaction with 7 steps

1: 79 percent / HC(OEt)3, p-TsOH*H₂O / CH₂Cl₂ / 7 h / Heating

2: 88 percent / benzene; diethyl ether / 3 h / 10 - 15 °C

3: 74 percent / p-TsOH*H₂O / formic acid / 7 h / 50 - 60 °C

4: 98 percent / BF₃*Et₂O / methanol / 2.5 h / 0 - 5 °C

5: 100 percent / NaBH₄ / methanol / 2 h / Ambient temperature

6: 94 percent / Na, liq. NH₃ / tetrahydrofuran / 0.5 h / -50 - -45 °C

7: 82 percent / Jones' reagent / acetone / 0.25 h / -15 - -10 °C

With sodium tetrahydroborate; jones' reagent; boron trifluoride diethyl etherate; ammonia; sodium; toluene-4-sulfonic acid; orthoformic acid triethyl ester; In tetrahydrofuran; methanol; formic acid; diethyl ether; dichloromethane; acetone; benzene;
DOI:10.1080/00304949709355234

Reference yield:

: 100071-90-7
18-methyl-estra-4-en-3,11,17-trione

: 54024-22-5
desogestrel

Guidance literature:: Multi-step reaction with 8 steps

1: 79 percent / HC(OEt)3, p-TsOH*H₂O / CH₂Cl₂ / 7 h / Heating

2: 88 percent / benzene; diethyl ether / 3 h / 10 - 15 °C

3: 74 percent / p-TsOH*H₂O / formic acid / 7 h / 50 - 60 °C

4: 98 percent / BF₃*Et₂O / methanol / 2.5 h / 0 - 5 °C

5: 100 percent / NaBH₄ / methanol / 2 h / Ambient temperature

6: 94 percent / Na, liq. NH₃ / tetrahydrofuran / 0.5 h / -50 - -45 °C

7: 82 percent / Jones' reagent / acetone / 0.25 h / -15 - -10 °C

8: 72 percent / n-C₄H₉Br, Li / tetrahydrofuran; diethyl ether / 1.) -10 deg C, 2 h; -5 deg C, 3 h, 2.) -5 deg C, 3 h

With 1-bromo-butane; sodium tetrahydroborate; jones' reagent; boron trifluoride diethyl etherate; ammonia; sodium; lithium; toluene-4-sulfonic acid; orthoformic acid triethyl ester; In tetrahydrofuran; methanol; formic acid; diethyl ether; dichloromethane; acetone; benzene;
DOI:10.1080/00304949709355234