3-[2-(tert-butyldimethylsilyloxy(3,5-dimethoxyphenyl)methyl)-1,3-dithian-2-yl]benzoic acid tert-butyldimethylsilyl ester

Base Information

Chemical Name:3-[2-(tert-butyldimethylsilyloxy(3,5-dimethoxyphenyl)methyl)-1,3-dithian-2-yl]benzoic acid tert-butyldimethylsilyl ester
CAS No.:1338833-49-0
Molecular Formula:C₃₂H₅₀O₅S₂Si₂
Molecular Weight:635.049
Hs Code.:

Synonyms:3-[2-(tert-butyldimethylsilyloxy(3,5-dimethoxyphenyl)methyl)-1,3-dithian-2-yl]benzoic acid tert-butyldimethylsilyl ester

Suppliers and Price of 3-[2-(tert-butyldimethylsilyloxy(3,5-dimethoxyphenyl)methyl)-1,3-dithian-2-yl]benzoic acid tert-butyldimethylsilyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[2-(tert-butyldimethylsilyloxy(3,5-dimethoxyphenyl)methyl)-1,3-dithian-2-yl]benzoic acid tert-butyldimethylsilyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[2-(tert-butyldimethylsilyloxy(3,5-dimethoxyphenyl)methyl)-1,3-dithian-2-yl]benzoic acid tert-butyldimethylsilyl ester

There total 4 articles about 3-[2-(tert-butyldimethylsilyloxy(3,5-dimethoxyphenyl)methyl)-1,3-dithian-2-yl]benzoic acid tert-butyldimethylsilyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1338833-48-9
3-[2-(hydroxy(3,5-dimethoxyphenyl)methyl)-1,3-dithian-2-yl]benzoic acid

: 69739-34-0
t-butyldimethylsiyl triflate

: 1338833-49-0
3-[2-(tert-butyldimethylsilyloxy(3,5-dimethoxyphenyl)methyl)-1,3-dithian-2-yl]benzoic acid tert-butyldimethylsilyl ester

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jo2017263

Reference yield:

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 1338833-49-0
3-[2-(tert-butyldimethylsilyloxy(3,5-dimethoxyphenyl)methyl)-1,3-dithian-2-yl]benzoic acid tert-butyldimethylsilyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1.83 h / -60 °C / Inert atmosphere

1.2: 1.17 h / -78 - 20 °C / Inert atmosphere

2.1: 2,6-dimethylpyridine / dichloromethane / 3 h / 20 °C

With 2,6-dimethylpyridine; n-butyllithium; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo2017263

Reference yield:

: 619-21-6
m-formylphenyl benzoic acid

: 1338833-49-0
3-[2-(tert-butyldimethylsilyloxy(3,5-dimethoxyphenyl)methyl)-1,3-dithian-2-yl]benzoic acid tert-butyldimethylsilyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate / acetic acid / 1.5 h / 75 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.83 h / -60 °C / Inert atmosphere

2.2: 1.17 h / -78 - 20 °C / Inert atmosphere

3.1: 2,6-dimethylpyridine / dichloromethane / 3 h / 20 °C

With 2,6-dimethylpyridine; n-butyllithium; boron trifluoride diethyl etherate; In tetrahydrofuran; hexane; dichloromethane; acetic acid;
DOI:10.1021/jo2017263