(R)-(4-aminophenyl)-(2-pyridyl) methanol

Base Information

Chemical Name:(R)-(4-aminophenyl)-(2-pyridyl) methanol
CAS No.:279263-04-6
Molecular Formula:C₁₂H₁₂N₂O
Molecular Weight:200.24
Hs Code.:
DSSTox Substance ID:DTXSID301271661

Synonyms:(R)-(4-aminophenyl)-(2-pyridyl) methanol;SCHEMBL5655181;FJEWOGSQQNYHFP-GFCCVEGCSA-N;DTXSID301271661;279263-04-6;(alphaR)-alpha-(4-Aminophenyl)-2-pyridinemethanol

Suppliers and Price of (R)-(4-aminophenyl)-(2-pyridyl) methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-(4-aminophenyl)-(2-pyridyl) methanol

Chemical Property:

XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:200.094963011
Heavy Atom Count:15
Complexity:190

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=NC(=C1)C(C2=CC=C(C=C2)N)O
Isomeric SMILES:C1=CC=NC(=C1)[C@@H](C2=CC=C(C=C2)N)O

Technology Process of (R)-(4-aminophenyl)-(2-pyridyl) methanol

There total 2 articles about (R)-(4-aminophenyl)-(2-pyridyl) methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-04-6
2-bromo-pyridine

: 279263-04-6
(R)-(4-aminophenyl)(pyridin-2-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: BuLi / diethyl ether; hexane / 1 h / -78 °C

1.2: 34 percent / diethyl ether; hexane; tetrahydrofuran / 3 h / -78 °C

2.1: 95 percent / H₂ / Pd/C / ethanol; ethyl acetate / 20 °C

3.1: hexane; ethanol

With n-butyllithium; hydrogen; palladium on activated charcoal; In diethyl ether; ethanol; hexane; ethyl acetate;
DOI:10.1248/cpb.52.818

Reference yield:

: 145654-38-2
2-(4-amino-α-hydroxybenzyl)pyridine

: 279263-05-7
(S)-(4-aminophenyl)(pyridin-2-yl)methanol

: 279263-04-6
(R)-(4-aminophenyl)(pyridin-2-yl)methanol

Guidance literature:: In ethanol; hexane;
DOI:10.1248/cpb.52.818

Reference yield:

: 7-[4-(2-butoxyethoxy)phenyl]-1-formyl-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid

: 279263-04-6
(R)-(4-aminophenyl)(pyridin-2-yl)methanol

: 7-[4-(2-butoxyethoxy)phenyl]-1-formyl-N-[4-[(R)-hydroxy(2-pyridyl)methyl]phenyl]-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: 7-[4-(2-butoxyethoxy)phenyl]-1-formyl-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.5h;

(R)-(4-aminophenyl)(pyridin-2-yl)methanol; With triethylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 72h;