2-(3-ethoxy-4-isopropoxyphenyl)-2-(isoquinolin-6-ylamino)acetic hydrochloride

Base Information

Chemical Name:2-(3-ethoxy-4-isopropoxyphenyl)-2-(isoquinolin-6-ylamino)acetic hydrochloride
CAS No.:745020-17-1
Molecular Formula:C₂₂H₂₄N₂O₄*ClH
Molecular Weight:416.904
Hs Code.:

Synonyms:2-(3-ethoxy-4-isopropoxyphenyl)-2-(isoquinolin-6-ylamino)acetic hydrochloride

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Chemical Property of 2-(3-ethoxy-4-isopropoxyphenyl)-2-(isoquinolin-6-ylamino)acetic hydrochloride

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Technology Process of 2-(3-ethoxy-4-isopropoxyphenyl)-2-(isoquinolin-6-ylamino)acetic hydrochloride

There total 4 articles about 2-(3-ethoxy-4-isopropoxyphenyl)-2-(isoquinolin-6-ylamino)acetic hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 745020-16-0
methyl 2-(3-ethoxy-4-isopropoxyphenyl)-2-(isoquinolin-6-ylamino)acetate

: 745020-17-1
2-(3-ethoxy-4-isopropoxyphenyl)-2-(isoquinolin-6-ylamino)acetic hydrochloride

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2013.06.027

Reference yield:

: 745020-15-9
C₁₄H₂₁NO₄

: 745020-17-1
2-(3-ethoxy-4-isopropoxyphenyl)-2-(isoquinolin-6-ylamino)acetic hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bi-2-naphthol / toluene / 100 °C

2: water; lithium hydroxide / tetrahydrofuran / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; caesium carbonate; lithium hydroxide; 1,1'-bi-2-naphthol; In tetrahydrofuran; toluene;
DOI:10.1016/j.bmcl.2013.06.027

Reference yield:

: 745020-14-8
2-amino-2-(3-ethoxy-4-isopropoxyphenyl)acetonitrile

: 745020-17-1
2-(3-ethoxy-4-isopropoxyphenyl)-2-(isoquinolin-6-ylamino)acetic hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water

2: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bi-2-naphthol / toluene / 100 °C

3: water; lithium hydroxide / tetrahydrofuran / 20 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; caesium carbonate; lithium hydroxide; 1,1'-bi-2-naphthol; In tetrahydrofuran; toluene;
DOI:10.1016/j.bmcl.2013.06.027