2-[2-methoxyethyl-(2,2,2-trifluoroacetyl)amino]-4-(4-methylpiperazin-4-ium-1-yl)benzoic acid 2,2,2-trifluoroacetate

Base Information

Chemical Name:2-[2-methoxyethyl-(2,2,2-trifluoroacetyl)amino]-4-(4-methylpiperazin-4-ium-1-yl)benzoic acid 2,2,2-trifluoroacetate
CAS No.:1034975-72-8
Molecular Formula:C₂HF₃O₂*C₁₇H₂₂F₃N₃O₄
Molecular Weight:503.399
Hs Code.:

Synonyms:2-[2-methoxyethyl-(2,2,2-trifluoroacetyl)amino]-4-(4-methylpiperazin-4-ium-1-yl)benzoic acid 2,2,2-trifluoroacetate

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Chemical Property of 2-[2-methoxyethyl-(2,2,2-trifluoroacetyl)amino]-4-(4-methylpiperazin-4-ium-1-yl)benzoic acid 2,2,2-trifluoroacetate

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Technology Process of 2-[2-methoxyethyl-(2,2,2-trifluoroacetyl)amino]-4-(4-methylpiperazin-4-ium-1-yl)benzoic acid 2,2,2-trifluoroacetate

There total 7 articles about 2-[2-methoxyethyl-(2,2,2-trifluoroacetyl)amino]-4-(4-methylpiperazin-4-ium-1-yl)benzoic acid 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 942471-28-5
tert-butyl 2-[2-methoxyethyl-(2,2,2-trifluoroacetyl)amino]-4-(4-methylpiperazin-1-yl)benzoate

: 76-05-1
trifluoroacetic acid

: 1034975-72-8
2-[2-methoxyethyl-(2,2,2-trifluoroacetyl)amino]-4-(4-methylpiperazin-4-ium-1-yl)benzoic acid 2,2,2-trifluoroacetate

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 20h;

Reference yield:

: 1034975-35-3
tert‐butyl 2‐amino‐4‐(4‐methylpiperazin‐1‐yl)benzoate

: 1034975-72-8
2-[2-methoxyethyl-(2,2,2-trifluoroacetyl)amino]-4-(4-methylpiperazin-4-ium-1-yl)benzoic acid 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 2 h / 100 °C

1.2: 0.33 h / Inert atmosphere

1.3: 16 h / 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

3.1: dichloromethane / 20 h / 0 - 20 °C

With hydrogenchloride; triethylamine; In dichloromethane; water;

Reference yield:

: 942271-61-6
tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate

: 1034975-72-8
2-[2-methoxyethyl-(2,2,2-trifluoroacetyl)amino]-4-(4-methylpiperazin-4-ium-1-yl)benzoic acid 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium on activated charcoal; hydrogen / ethanol / 6 h / 760.05 Torr

2.1: hydrogenchloride / water / 2 h / 100 °C

2.2: 0.33 h / Inert atmosphere

2.3: 16 h / 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

4.1: dichloromethane / 20 h / 0 - 20 °C

With hydrogenchloride; palladium on activated charcoal; hydrogen; triethylamine; In ethanol; dichloromethane; water;